A0A182QR49 · A0A182QR49_9DIPT

Function

function

Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoskeleton
Cellular Componentneuron projection
Cellular Componentperinuclear region of cytoplasm
Cellular Componentplasma membrane
Cellular Componentpostsynaptic density
Cellular Componentpostsynaptic early endosome
Cellular Componentsynaptic vesicle
Cellular Componenttrans-Golgi network membrane
Molecular Functionactin binding
Molecular Functionphospholipid binding
Molecular Functionprotein domain specific binding
Molecular Functionprotein kinase C binding
Biological Processdendritic spine maintenance
Biological Processintracellular protein transport
Biological Processpositive regulation of receptor internalization
Biological Processreceptor clustering
Biological Processregulation of Arp2/3 complex-mediated actin nucleation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    PRKCA-binding protein
  • Alternative names
    • Protein interacting with C kinase 1
    • Protein kinase C-alpha-binding protein

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • FAR1
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles

Accessions

  • Primary accession
    A0A182QR49

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm, cytoskeleton
Cytoplasm, perinuclear region
Membrane
; Lipid-anchor
Membrane
; Peripheral membrane protein
Postsynaptic density
Synapse, synaptosome

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Monomer and homodimer. Interacts with CXADR. Interacts presynaptically with the glutamate receptors GRIA2, GRIA3, GRIK3, isoform 3 of GRIA4, isoform A of GRM4, GRM7 and GRM8; with NAPA and NAPB; and with BTG2. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with PRKCA; with the amine transporters SLC6A2 and SLC6A3; with the channels ASIC1 and ASIC2; with the GTP-binding proteins ARF1 and ARF3; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; with ERBB2 and through its PDZ domain with the C-terminal tail of PRLHR. Interacts with UNC5A. Interacts (via AH domain) with NCS1/FREQ; in a calcium-dependent manner. Interacts with F-actin and associates with the ARP2/3 complex. Interacts (via PDZ domain) with ARF1 (activated); the interaction blocks Arp2/3 complex inhibition.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region85-121Disordered
Compositional bias98-121Basic and acidic residues
Domain172-255PDZ
Domain294-507AH
Region537-571Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    631
  • Mass (Da)
    70,313
  • Last updated
    2016-09-07 v1
  • MD5 Checksum
    FD4AE654A15BE4AEFFD96D5E20F830EC
DRFQQVFQHSFSYHIVIIRKTLPVSVIVLGAKINRTTMLQDCDYDYFYEEDKISNVSNQSRPPAKTFLIDEEAGRDDEQVLISIGSETGSGPKSVSSQHRPEAKDNVNGSDDAKPEKDKATAKRMDEIAFVSNDDLPDPVLYADGCVDDNKIIMLCQRQEMERLGMTVSSGTVLIKKDTSNLIGISIGGGAPLCPCLYIVQVFDGTPAAREGTLQSGDELLGVNGASVKGKTKVEVAKMIQSATDEVMIHYNKLHADPTQGETLDIVLKKMKHRLVERMSSSTADTLGLSRAILCNDSLVKRLQELERTETMYKGLVEHARRMLKAHFDVLQTYQAFGNIFASISVREPQPRASEAFRIFGELHRNMEKDGIKMIKSLKPILADMGTYLHKAIPDTKLTVKRYADAKFSYLSYCLKIKEMDDEEHGYAAIQEPLYRVETGNYEYRLILRCRQEARLKFAKLRSDVLEKIELLECKHARDLAGQLRKFIEGLATLATETVERLESIPNLFPIEVDLKASAFQYKSAIKFQAEEYTDEEVPQAEEAIEQAPAPRSGEASTIDRDLERANGGDDGSDQLLGGFEEIDLNKGAAVGSTENDLLNELGLAGIDLSVGSKPISHNLMDDLLVPELFK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias98-121Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AXCN02000606
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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