A0A182QE70 · A0A182QE70_9DIPT

  • Protein
    Inosine triphosphate pyrophosphatase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site9-14ITP (UniProtKB | ChEBI)
Binding site39Mg2+ (UniProtKB | ChEBI)
Binding site51ITP (UniProtKB | ChEBI)
Binding site67Mg2+ (UniProtKB | ChEBI)
Binding site67-68ITP (UniProtKB | ChEBI)
Binding site143-146ITP (UniProtKB | ChEBI)
Binding site166ITP (UniProtKB | ChEBI)
Binding site171-172ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular FunctionXTP diphosphatase activity
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • FAR1
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles

Accessions

  • Primary accession
    A0A182QE70

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    188
  • Mass (Da)
    21,230
  • Last updated
    2016-09-07 v1
  • MD5 Checksum
    C37425450E679FA8F11864EB441BC079
MARPISFVTGNAKKLEEVRAILGSRFPREIIAVKLDLPELQGEIDDICKRKCLEAARQVQGPVMVEDTCLCFNALKGLPGPYIKWFLDKLGPEGLHKLLDGWEDKSAQAVCTFAYAPDPNSEVILFQGRTDGDIVAPRGPRDFGWDPVFQPTGYEQTYAELPKEKKNEISHRFRALDKLREHFAKESN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AXCN02000807
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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