A0A182Q0Z2 · A0A182Q0Z2_9DIPT

  • Protein
    Phosphodiesterase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Features

Showing features for active site, binding site.

1845100200300400500600700800
Type
IDPosition(s)Description
Active site558Proton donor
Binding site558-562AMP (UniProtKB | ChEBI)
Binding site562Zn2+ 1 (UniProtKB | ChEBI)
Binding site600Zn2+ 1 (UniProtKB | ChEBI)
Binding site601AMP (UniProtKB | ChEBI)
Binding site601Zn2+ 2 (UniProtKB | ChEBI)
Binding site601Zn2+ 1 (UniProtKB | ChEBI)
Binding site710AMP (UniProtKB | ChEBI)
Binding site710Zn2+ 1 (UniProtKB | ChEBI)
Binding site761AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial matrix
Cellular Componentmitochondrial outer membrane
Cellular Componentnucleus
Cellular Componentperinuclear region of cytoplasm
Cellular Componentsynaptic membrane
Molecular Function3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
Molecular Functioncalmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
Molecular Functioncalmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
Molecular Functionmetal ion binding
Molecular Functionprotein homodimerization activity
Biological ProcesscAMP-mediated signaling
Biological ProcesscGMP catabolic process
Biological ProcesscGMP-mediated signaling
Biological Processnegative regulation of cAMP-mediated signaling
Biological Processnegative regulation of cGMP-mediated signaling
Biological Processpositive regulation of gene expression
Biological Processregulation of mitochondrion organization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • FAR1
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles

Accessions

  • Primary accession
    A0A182Q0Z2

Proteomes

Organism-specific databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-48Disordered
Compositional bias24-45Polar residues
Domain476-804PDEase
Region798-818Disordered
Compositional bias802-816Polar residues

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    845
  • Mass (Da)
    94,274
  • Last updated
    2016-09-07 v1
  • MD5 Checksum
    EB3D025C801EE1DA84C7566E65140B48
MSYNADDCPDSDTAVAGGNGGGGGGGTGSSSSELNCTTPSSPGMTRQDAVVLHGDGGSIDDGADVIPGAPPMVVSSSGYEPCDPLIILNLFQSLSATTNSLELQMKINLHLKALTRSPYVFLVPILHSSEEGLIQVINDNVLDKEIRFSINSSHFRSGSHHNGYPFVIDDLNKDFSEVIEMVVGNKHNTLIYDILGPKVSKLQSQTSTTSASSTSSLNELNFNSSVQSQQAPHNGPTLAAQHQQQIALFVCIAGDSSSRSRYQFYIDDTFRYVLGHLVTAFELYEEKRVRDQCQNLLQVARRLLGKIGDLGQLLRGVMTEAKELAAAERCSLFLLDKHTGELVSKVFDGNEASKEIRIESGKGIAGYVAQTGKLLNIRNAYQHPLFYKGVDESTGFKTRNILCFPICDEEGVIGVAQLCNKLNGFHFDKCDEEVATAFSVYCGISIMHALVHKQVQKAEARYKLSQELLLYHMKVPDVEVNHALEAVKEPDREQDEQYRAFPRFNFCPRDVKDHARSVQLSMRMFYDLNFVGSFKIHENKLARFVLLVQKGYRDTPYHNWWHAFSVAHFAYSLMMNLRLIERGIITKMQGFSFLIAAFCHDLDHRGISNSYQTQTSSPLARLYSSEGSVNERHHLSQAICILNDSSSKILDGLSTTEFKECIDYLRELILATDLANHFRILPRLKRLRAENLAEGANQRLLLSLMITCCDLNDQIKSWKTVQHVAHLVYAEFFAEGDLEKQMGLRPNAMMDRKKACIPMLQIEFLTTVIRPTFEILVQIFPETHPFLDTIDSNREQWERVRNRAAQQQQPGNGNGTAGNGAPEPCNGCNATAECCDFTCYTQVNE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias24-45Polar residues
Compositional bias802-816Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AXCN02000801
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AXCN02000802
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AXCN02000803
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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