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A0A182F9F2 · A0A182F9F2_ANOAL

Function

function

Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Lipid metabolism; fatty acid biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionvery-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity
Biological Processfatty acid elongation
Biological Processsphingolipid biosynthetic process
Biological Processvery long-chain fatty acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
  • EC number

Organism names

  • Taxonomic identifier
  • Strain
    • ALBI9_A
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles

Accessions

  • Primary accession
    A0A182F9F2

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-41Helical
Transmembrane53-76Helical
Transmembrane125-144Helical
Transmembrane191-211Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the very long-chain fatty acids dehydratase HACD family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    233
  • Mass (Da)
    26,488
  • Last updated
    2016-09-07 v1
  • MD5 Checksum
    C8BADD5D94DDDE3811F7F619234F0B69
MAQHKKNEPSTTVKAYLVLYNLTQLAGWSYIFVQFVTHFFLRGHGLSGLWREVGSATFFFQMLAPLEVVHAAIGIVPSNVPMTFLQVFGRCMVVAGAIDGTPTGQQSPGLPLALFCWSLTEIVRYAYYVANLLLASVPAPLVWLRYTIFIPMYPCGFFGELLCGYWAQSYFKETGKWSVTLPNPANFTFSFYYFICIMTVSYLPLFPQMYLHMFSQRRKVLGRTEQSSGKKVR

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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