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A0A182F1M2 · A0A182F1M2_ANOAL

Function

function

Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs. Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

GO annotations

AspectTerm
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionmetal ion binding
Molecular FunctionRNA binding
Molecular FunctiontRNA dihydrouridine synthase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA-dihydrouridine(47) synthase [NAD(P)(+)]
  • EC number
  • Alternative names
    • tRNA-dihydrouridine synthase 3

Organism names

  • Taxonomic identifier
  • Strain
    • ALBI9_A
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles

Accessions

  • Primary accession
    A0A182F1M2

Proteomes

Organism-specific databases

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the dus family. Dus3 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    619
  • Mass (Da)
    70,262
  • Last updated
    2016-09-07 v1
  • MD5 Checksum
    116DCEFD9C34A772EF79B5906D1EF890
MDDGICHIKAEYLIPRAVIEKPAEHAEPTLPATAEQESENKPAGKDGDGPPAEKKGRYESEGKKKKNRGQNKGRQLPFKEDDSLRLCKSLLDGPQQEGSEKKCSNPNCRYSHDLERFLQLKPKDIGDKCYIYSVKGYCNFGVTCRFAGAHLDEQNRNIYPADHKTDDDSMLVSTWLSTDLQHILRKKKYNFNKSTKIVNKFERLQQEERAEKAKVAAAEPSNGEAETVISEAVEKGVETETPVAVPIGPVTDEDLIILRSGERKRINFRDKLYLSPLTTVGNLPFRRICKEYGVDITCGEMACAIPIINGAIQEWALTKRHASEDLFGVQLCGHKPKLVTYAAQIIAEKADVDFIDLNIGCPIDLIFNQGGGSALLRRQNVLQVMVQSCSRLLADYGKEFTVKTRIGIYNNKPIAHELVPRFEEWGASLITIHGRTKEQRYTKHADWEFVQRCAAQARSVPVYGNGDIYCYSDYETARERCPNVGGVMVGRGALIKPWVFQEIKERKNLDPSSSERFEMLKRYVNYGLEHWGSDTKGVENTRRFLLEWQSFLYRYVPYGLLERPPQRINQRPEAFRGRDDLETLMASPNCNDWVKLSEMLLGPVPEGFNFVPKHKANAY

Genome annotation databases

Similar Proteins

Disclaimer

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