A0A182F1M2 · A0A182F1M2_ANOAL
- ProteintRNA-dihydrouridine(47) synthase [NAD(P)(+)]
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids619 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs. Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation.
Catalytic activity
- 5,6-dihydrouridine47 in tRNA + NAD+ = uridine47 in tRNA + NADH + H+This reaction proceeds in the backward direction.
- a 5,6-dihydrouridine in mRNA + NAD+ = a uridine in mRNA + NADH + H+This reaction proceeds in the backward direction.
- a 5,6-dihydrouridine in mRNA + NADP+ = a uridine in mRNA + NADPH + H+This reaction proceeds in the backward direction.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | metal ion binding | |
Molecular Function | RNA binding | |
Molecular Function | tRNA dihydrouridine synthase activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA-dihydrouridine(47) synthase [NAD(P)(+)]
- EC number
- Alternative names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles
Accessions
- Primary accessionA0A182F1M2
Proteomes
Organism-specific databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length619
- Mass (Da)70,262
- Last updated2016-09-07 v1
- MD5 Checksum116DCEFD9C34A772EF79B5906D1EF890