A0A179D368 · A0A179D368_9BACT

Function

function

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.

Pathway

Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site93Proton donor/acceptor
Active site155Schiff-base intermediate with acetaldehyde
Active site184Proton donor/acceptor
Binding site235Mg2+ 2 (UniProtKB | ChEBI)
Binding site235Mg2+ 1 (UniProtKB | ChEBI)
Binding site273Mg2+ 1 (UniProtKB | ChEBI)
Binding site295Mg2+ 1 (UniProtKB | ChEBI)
Binding site359Mg2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functiondeoxyribose-phosphate aldolase activity
Molecular Functionmagnesium ion binding
Molecular Functionnucleic acid binding
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Biological Process2-deoxyribose 1-phosphate catabolic process
Biological Processcarbohydrate catabolic process
Biological Processdeoxyribonucleotide catabolic process
Biological ProcessRNA catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Deoxyribose-phosphate aldolase
  • EC number
  • Short names
    DERA
  • Alternative names
    • 2-deoxy-D-ribose 5-phosphate aldolase
    • Phosphodeoxyriboaldolase
      (Deoxyriboaldolase
      )
  • Recommended name
    Ribonuclease H
  • EC number
  • Short names
    RNase H

Gene names

    • Name
      rnhA
    • Synonyms
      deoC
    • ORF names
      TDIS_1416

Organism names

  • Taxonomic identifier
  • Strain
    • S95
  • Taxonomic lineage
    Bacteria > Thermodesulfobacteriota > Thermodesulfobacteria > Thermodesulfobacteriales > Thermodesulfobacteriaceae > Thermosulfurimonas

Accessions

  • Primary accession
    A0A179D368

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain226-367RNase H type-1

Sequence similarities

Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
Belongs to the RNase H family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    375
  • Mass (Da)
    41,039
  • Last updated
    2016-09-07 v1
  • Checksum
    E003DE5F426DB5B3
MPKLFNPAPYIDHTLLAPTATEKDIKKLCSEAQEYGMAGVCVPPVFVPLARKELSGTGIRVVTVAGFPLGFQPTEVKVHEARLYRDLGADEIDMVINLHLTKNGRVREAVEEVKQVVKAANPTEVKVIIECAYLKAEEKKLLAELIPGTGAAYLKTSTGFGPGGATLEDVKLLREASGGKIKIKAAGGIRTLEECLAFIQAGAERIGTSAGASIVREYLARTGQLPYEEVEIFIDGACLGNPGPGGFSAILRARGHEKVLTGGEAETTNNRMEIRAAVEALKALKKPSRVKMYTDSKYLLSGATDWLPRWEKRGFRTADGKPVKNRDLWEELSRLLKIHEVEWIWIEGHAGHPENERCDKLAKNEAKKWKNSSSA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LWLG01000010
EMBL· GenBank· DDBJ
OAQ20507.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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