A0A178Z4C3 · A0A178Z4C3_9EURO

  • Protein
    DNA-(apurinic or apyrimidinic site) endonuclease 2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Probably binds two magnesium or manganese ions per subunit.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, active site, site.

160350100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site9Mg2+ 1 (UniProtKB | ChEBI)
Binding site44Mg2+ 1 (UniProtKB | ChEBI)
Active site157
Active site196Proton donor/acceptor
Binding site196Mg2+ 1 (UniProtKB | ChEBI)
Binding site198Mg2+ 1 (UniProtKB | ChEBI)
Site198Transition state stabilizer
Site288Important for catalytic activity
Binding site313Mg2+ 1 (UniProtKB | ChEBI)
Active site314Proton acceptor
Binding site314Mg2+ 1 (UniProtKB | ChEBI)
Site314Interaction with DNA substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functiondouble-stranded DNA 3'-5' DNA exonuclease activity
Molecular Functionendonuclease activity
Molecular Functionphosphoric diester hydrolase activity
Molecular Functionzinc ion binding
Biological Processbase-excision repair

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    DNA-(apurinic or apyrimidinic site) endonuclease 2

Gene names

    • ORF names
      AYL99_11035

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CBS 125763
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Chaetothyriomycetidae > Chaetothyriales > Herpotrichiellaceae > Fonsecaea

Accessions

  • Primary accession
    A0A178Z4C3

Proteomes

Subcellular Location

Keywords

  • Cellular component

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias423-442Polar residues
Region423-519Disordered
Compositional bias458-489Polar residues
Domain543-595GRF-type

Sequence similarities

Belongs to the DNA repair enzymes AP/ExoA family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    603
  • Mass (Da)
    67,357
  • Last updated
    2016-09-07 v1
  • Checksum
    E5021A8025CF0A0D
MGIRITTWNVNGIRNPFGYQPWRDKRTFEGMFDILEADMVIFQETKIQRKDLRDDMVLVPGWDNYWSLPKHKKGYSGVVIYTRNATCAPIKAEEGITGILTPPNSSTSFRDLPDEDQIGGYPNAEQLSEADYDPATLDSEGRCVILEFPAFVLIGTYCPAERDETRTHYRTSYLRVLDARIRNLVKMGKRVVWAGDFNISREEIDTAAAQENMRKNGVDPVQWISTPARRMFNQLLVGGKVHGDRDEGRERPIMWDLCRAFHEGRKGMYTCWETKVNARPGNYGSRIDYVVCSYDMKDWFSDANIQEGLMGSDHCPVYAVLKDTVFVDGVGRHILDLVNPPGMFVDGVRKQEWTTKCLLPTSGKLIQEFDKRQSIRDMFTRKPSVLKSKSSIDETDTNGVVLDAPLTTAIVGADNLTRSEADDTGALSKTVSNVSSNSKGISAKRPARAPEAPTVAKRSKTAPQTTPNGVGKGQQSLRGFFSTRPATAQTPEVDEPVTEAKREEASEEPLMPQAPPSLEEEAASFSARQTWGKLFSKPVAPKCEHGEPCKTMLTKKPGANCGRSFWMCARPLGPSGKQEKGTQWRCNTFIWASDWDAHGTEPS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias423-442Polar residues
Compositional bias458-489Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LVYI01000013
EMBL· GenBank· DDBJ
OAP54587.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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