A0A178VKQ6 · A0A178VKQ6_ARATH

Function

function

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site643-648ATP (UniProtKB | ChEBI)
Binding site669a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site690-692a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site717-720a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site724CMP (UniProtKB | ChEBI)
Binding site756ATP (UniProtKB | ChEBI)
Binding site760a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site771a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site799ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionCMP kinase activity
Molecular FunctiondCMP kinase activity
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular FunctionUMP kinase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Processpyrimidine nucleotide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UMP-CMP kinase
  • EC number
  • Alternative names
    • Deoxycytidylate kinase
      (CK
      ; dCMP kinase
      )
    • Uridine monophosphate/cytidine monophosphate kinase
      (UMP/CMP kinase
      ; UMP/CMPK
      )

Gene names

    • Ordered locus names
      AXX17_At3g54590

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Landsberg erecta
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    A0A178VKQ6

Proteomes

Subcellular Location

Keywords

Expression

Gene expression databases

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain37-306Dynamin-type G
Domain532-625GED

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    816
  • Mass (Da)
    91,480
  • Last updated
    2016-09-07 v1
  • Checksum
    941BC1DE69BDB038
MTTMESLIGLVNRIQRACTVLGDYGGGTGSNAFNSLWEALPTVAVVGGQSSGKSSVLESIVGRDFLPRGSGIVTRRPLVLQLHKTDDGTEEYAEFLHLPKKQFTDFALVRREIQDETDRITGKNKQISPVPIHLSIYSPNVVNLTLIDLPGLTKVAVEGQPETIAEDIESMVRTYVDKPNCIILAISPANQDIATSDAIKLAKDVDPTGERTFGVLTKLDLMDKGTNALEVLEGRSYRLQHPWVGIVNRSQADINKNVDMMLARRKEREYFDTSPDYGHLASKMGSEYLAKLLSKHLESVIRTRIPSILSLINKSIEELERELDRMGRPVAVDAGAQLYTILEMCRAFDKIFKEHLDGGRPGGDRIYGVFDNQLPAALKKLPFDRHLSLQSVKKIVSEADGYQPHLIAPEQGYRRLIEGALGYFRGPAEASVDAVHYVLKELVRKSISETEELKRFPSLQVELAAAANSSLEKFREESKKSVIRLVDMESAYLTAEFFRKLPQEIERPVTNSKNQTASPSSATLDQYGDGHFRRIASNVSAYVNMVSDTLRNTIPKACVYCQVRQAKLALLNYFYSQISKREGKQLGQLLDEDPALMDRRLECAKRLELYKKARDEIDAVAWDEHECPRWKKSTVVFVLGGPGSGKGTQCANVVKHFSYTHFSAGDLLRAEIKSGSEFGAMIQSMIAEGRIVPSEITVKLLCKAMEESGNDKFLIDGFPRNEENRNVFENVARIEPAFVLFFDCPEEELERRIMSRNQGREDDNIETIKKRFKVFVESTLPIISYYESKGKLRKINAAKSSEEVFEAVRVLFASET

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LUHQ01000003
EMBL· GenBank· DDBJ
OAP06344.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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