The active and inactive AtNUDX6 proteins induced the expression of thioredoxin-h5 while the active and inactive AtNUDX7 proteins suppressed the accumulation of SA and subsequent gene expression indicating that AtNUDX6 and 7 proteins themselves play distinct roles in stress responses. [AtNUDX7]
AtNUDT7 protein levels are induced in response to biotic and abiotic stresses. AtNUDT7 plays an important role in maintaining redox homeostasis particularly for maintaining NADH:NAD+ balance for normal growth and development.
Under oxidative stress AtNUDX7 serves to maintain NAD(+) levels by supplying ATP via nucleotide recycling from free ADP-Rib molecules and thus regulates the defense mechanisms against oxidative DNA damage via modulation of the PAR reaction. [AtNUDX7]
structure-activity studies: mutation of specific residues in AtNUDT7 alters function; mutation of residues F73 & V168 disallows dimer formation & enzymatic activity; mutation of residues V69 F73 & V168 disrupts binding to regulatory 14-3-3 protein
A role for poly(ADP-ribosyl)ation in plant defense responses was suggested initially by the upregulated expression of genes encoding NUDT7 and poly(ADP-ribose) glycohydrolase in multiple R-avr interactions.
FMO1 and NUDT7 are important for signaling through an EDS1-dependent but SA-independent branch of plant defense and NUDT7 exerts negative control of EDS1 signaling. [NUDT7]
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