A0A177PP06 · A0A177PP06_9HYPH

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site13-18substrate
Binding site45Mg2+ (UniProtKB | ChEBI)
Active site74Proton acceptor
Binding site74Mg2+ (UniProtKB | ChEBI)
Binding site75substrate
Binding site158-161substrate
Binding site181substrate
Binding site194-195substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      A1351_04720

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • R-45379
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Methylocystaceae > Methylosinus

Accessions

  • Primary accession
    A0A177PP06

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    208
  • Mass (Da)
    22,286
  • Last updated
    2016-09-07 v1
  • Checksum
    C17E8D6B6F5702DE
MTRRIEGRLVIATHNPGKLWELRQLLEPHGVDAVSAGELGVAEPEETETTFSGNALLKARASCAATGLPAFADDSGLCVDGLDGAPGVYSARWGGDNRDFSSAIRRVERELNERGATAPFAAHFICALAIVWPDGHVEEFEGRVDGVLVFPPRGEKGFGYDPIFLPDGLDRTFGEMMSAEKHALPGDGSRALSHRARAFQALARACLA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LUUM01000002
EMBL· GenBank· DDBJ
OAI31752.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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