A0A177B5H2 · A0A177B5H2_9BILA
- ProteinMediator of RNA polymerase II transcription subunit 4
- GeneMED4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids405 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Catalytic activity
- 2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine
Pathway
Purine metabolism; purine nucleoside salvage.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | mediator complex | |
Molecular Function | purine-nucleoside phosphorylase activity | |
Molecular Function | transcription coregulator activity | |
Biological Process | nucleoside metabolic process | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMediator of RNA polymerase II transcription subunit 4
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Mesozoa > Orthonectida > Rhopaluridae > Intoshia
Accessions
- Primary accessionA0A177B5H2
Proteomes
Subcellular Location
Interaction
Subunit
Component of the Mediator complex.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 78-171 | Nucleoside phosphorylase | |||
Sequence similarities
Belongs to the Mediator complex subunit 4 family.
Belongs to the PNP/MTAP phosphorylase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length405
- Mass (Da)46,650
- Last updated2016-09-07 v1
- MD5 Checksum81C310210EA859184004CE9AA4FF21DB
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LWCA01000292 EMBL· GenBank· DDBJ | OAF69370.1 EMBL· GenBank· DDBJ | Genomic DNA |