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A0A177B5H2 · A0A177B5H2_9BILA

  • Protein
    Mediator of RNA polymerase II transcription subunit 4
  • Gene
    MED4
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; purine nucleoside salvage.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmediator complex
Molecular Functionpurine-nucleoside phosphorylase activity
Molecular Functiontranscription coregulator activity
Biological Processnucleoside metabolic process
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mediator of RNA polymerase II transcription subunit 4
  • Alternative names
    • Mediator complex subunit 4

Gene names

    • Name
      MED4
    • ORF names
      A3Q56_02886

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Intl2013
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Mesozoa > Orthonectida > Rhopaluridae > Intoshia

Accessions

  • Primary accession
    A0A177B5H2

Proteomes

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Component of the Mediator complex.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain78-171Nucleoside phosphorylase

Sequence similarities

Belongs to the Mediator complex subunit 4 family.
Belongs to the PNP/MTAP phosphorylase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    405
  • Mass (Da)
    46,650
  • Last updated
    2016-09-07 v1
  • MD5 Checksum
    81C310210EA859184004CE9AA4FF21DB
MNSSNLYDETEHYLRGLMNKYKIPKPSVLIICGNGLRHITDNLHFIFELDYDNIPNFPKTTVEGHMAEIQYVGFSIQGRIRYHRGVLTMINGPTYPTVAEAKFLKMIGGDMEGMITCPEHIVAHNCAIKNFGLSLIAAHVVDKYDSNDHVNHKGVLETTEKYSKIISNVVSKTKESGGYKIEHLTNFLAYSNKNLEQNIRNLQKQEELTQKLENVNSIIEKYDSVIKVYLNEMKTAETILSETLGQLEDLLIPINKHCNTDIEVNDIMAYSEFLSNFSSSFMPSDWKFGDSRRPYPTNEDVRKGVLIDFEKMDINDSERLKSYYEHRSDTSKLTDPKKLNLVTTELFINFEKENLNNLSLSTPQITEKPNEIKKCLTMTELSEWVKEESTHYDENVQSSCYNYDD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LWCA01000292
EMBL· GenBank· DDBJ
OAF69370.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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