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A0A177B2T6 · A0A177B2T6_9BILA

  • Protein
    DNA topoisomerase 2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Molecular Functionmetal ion binding
Biological ProcessDNA topological change
Biological Processresolution of meiotic recombination intermediates
Biological Processsister chromatid segregation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase 2
  • EC number

Gene names

    • ORF names
      A3Q56_03822

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Intl2013
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Mesozoa > Orthonectida > Rhopaluridae > Intoshia

Accessions

  • Primary accession
    A0A177B2T6

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain446-563Toprim
Region1320-1383Disordered
Compositional bias1326-1377Basic and acidic residues
Compositional bias1396-1410Polar residues
Region1396-1500Disordered
Compositional bias1425-1444Basic and acidic residues
Compositional bias1453-1480Basic and acidic residues
Compositional bias1484-1500Polar residues

Sequence similarities

Belongs to the type II topoisomerase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,500
  • Mass (Da)
    172,652
  • Last updated
    2016-09-07 v1
  • MD5 Checksum
    163D2EDDA3EBABE9E8E5A95ACADD62A0
MKYSSQSKSVTKKHNEGTIEKIYQKKTQLEHILLRPDTYIGSIEKITQLMWVFDEEKNHMIKKEISFVPGLYKIFDEIIVNAADNKVRDSNMDCIKIKISREENMISIWNNGKSVPIVMHKVEKMYVPSLIFGQLLTSSNYDDTKKKVTGGRNGYGAKLCNAFSVKFTLETQSRSGRKKFKQTWKDNMSTEGEPKIVPIERAAGDDYTRVSFSPDLKRFGMETLEDDIIMLFKRRAYDICAVSKCKVFLNGEKIPIKNFKDFVDLHIRGMKDELGQPLNIAYDKQERWEIALTVSDTGFQHSSFVNSIATTKGGRHVDYIADQIVSKILEAVKKKQKKGSVEIKPFQVKNHLFLFLNVQIENPQFDSQTKENFTSAVRSFGSKCVISDKFVTQVIKLGIVDSILNWAALKSQDILNKKSGVKTCRLRGIPKLEDANNAGTKNSINCTLILTEGDSAKTLAVSGLSVVGRNLYGVFPLRGKVLNVREASHKQIMENAEINNIIKIMGLKYKDKYVDRDSLKSLRYGKILIMTDQDQDGSHIKGLLINFIHYNWPNLLQHKFLDEFITPIVKVSKRGNSQSFYSMPEFEIWKNETENWQTFNIKYYKGLGTSTSKEAKEYFQDLDRHLINFKYDGNEDDKSIELAFSKKKIEQRKVWLTNWMEKRRERILHDLPEEYLYKPNLHKISYTDFVNKELVLFSNMDNERSIPSLVDGFKPGQRKVMYTCFKRNLIKELKVAQLSGSVAELSAYHHGEVSLMATIINLAHDFVGSNNINLLMPNGQFGTRLAGGKDAASPRYIFTCLNAITRKIFRPEDDSILSYTYDDTFKTEPKYYVPILPMILVNGCEGIGTGWSTKIPNYNPIDIVNNLKRLLKDEEMKPMMPYYRGYRGEILEFDSSKYITCGELAVLDNNSIEISELPIKVWTQTYKENVIESLMYSNDNKNGLVTDYSEYHTDTTVRFVLKVKSELFNKHHDSAMYKYLKLQSSISTNSMVLFDSNGCIKRFSNVSEMMKEFYIVRLKYYLIRKKYMVGLLTAEAKKYSNQARFIIEYSSKKIVIDNVPRKKIIEILIDGKYDSDPIKKWNEKQKIENVDQSNEEEQDSNETHDFNYILNMSLWTLSKEKREELLKQKGDKLLELSNLEKLSAKDLWLSDLEEFLVAYRAFLDEKESELKSALNPKMKKKGTSLYTKKDNNLVPSKYADRIAPKIDQASLDLKKKVELKAKIKLEKDKQVKVDNVKSGKIIDVKLEKVDNVDETEFKSLYERIGVDPVTKKRNNNDIKATKMKKIKLDSKKEKIVDDSCSDNDLKKNKKKDITLDSSDSELESISQLSKTKKRKNDDIKPTKTKKFKLDSKKEKIFDHSCSHNDLKKNEKKNLTLNSSDSELESISQLSKTKKLYLFGNSNNKSTNKKGPLDSSDSDQDIIDVSQSPIKKKRNAKDKSTKKNIASDNSDSSIEEVKLVRAKRETKPIKYNLKSEDSESNSEESESNSDFVSDLSQSSFE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1326-1377Basic and acidic residues
Compositional bias1396-1410Polar residues
Compositional bias1425-1444Basic and acidic residues
Compositional bias1453-1480Basic and acidic residues
Compositional bias1484-1500Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LWCA01000443
EMBL· GenBank· DDBJ
OAF68460.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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