A0A177B2T6 · A0A177B2T6_9BILA
- ProteinDNA topoisomerase 2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1500 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Catalytic activity
Cofactor
Protein has several cofactor binding sites:
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | |
Molecular Function | metal ion binding | |
Biological Process | DNA topological change | |
Biological Process | resolution of meiotic recombination intermediates | |
Biological Process | sister chromatid segregation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA topoisomerase 2
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Mesozoa > Orthonectida > Rhopaluridae > Intoshia
Accessions
- Primary accessionA0A177B2T6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 446-563 | Toprim | |||
Region | 1320-1383 | Disordered | |||
Compositional bias | 1326-1377 | Basic and acidic residues | |||
Compositional bias | 1396-1410 | Polar residues | |||
Region | 1396-1500 | Disordered | |||
Compositional bias | 1425-1444 | Basic and acidic residues | |||
Compositional bias | 1453-1480 | Basic and acidic residues | |||
Compositional bias | 1484-1500 | Polar residues | |||
Sequence similarities
Belongs to the type II topoisomerase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,500
- Mass (Da)172,652
- Last updated2016-09-07 v1
- MD5 Checksum163D2EDDA3EBABE9E8E5A95ACADD62A0
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1326-1377 | Basic and acidic residues | |||
Compositional bias | 1396-1410 | Polar residues | |||
Compositional bias | 1425-1444 | Basic and acidic residues | |||
Compositional bias | 1453-1480 | Basic and acidic residues | |||
Compositional bias | 1484-1500 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LWCA01000443 EMBL· GenBank· DDBJ | OAF68460.1 EMBL· GenBank· DDBJ | Genomic DNA |