A0A176VE92 · A0A176VE92_MARPO

Function

function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Allosterically activated by AMP.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site202ATP (UniProtKB | ChEBI)
Binding site266-267ATP (UniProtKB | ChEBI)
Binding site291-294ATP (UniProtKB | ChEBI)
Binding site292Mg2+ (UniProtKB | ChEBI); catalytic
Site293Important for substrate specificity; cannot use PPi as phosphoryl donor
Binding site320-322substrate
Active site322Proton acceptor
Binding site365-367substrate
Binding site421substrate
Binding site473-476substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function6-phosphofructokinase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processfructose 6-phosphate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent 6-phosphofructokinase
  • EC number
  • Short names
    ATP-PFK
    ; Phosphofructokinase
  • Alternative names
    • Phosphohexokinase

Gene names

    • Name
      PFK
    • ORF names
      AXG93_2396s1460
      , Mp_5g11490

Organism names

  • Taxonomic identifier
  • Strains
    • cv. Tak-1 and cv. Tak-2
    • Tak-1
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Marchantiophyta > Marchantiopsida > Marchantiidae > Marchantiales > Marchantiaceae > Marchantia

Accessions

  • Primary accession
    A0A176VE92

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region52-85Disordered
Domain195-497Phosphofructokinase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    554
  • Mass (Da)
    60,611
  • Last updated
    2016-09-07 v1
  • Checksum
    53A419448BF463D9
MALVAATPLHSPVVSVSCRQLEGRTLKTSFLQPRAVVPFSIRSWNLSAPADRLRGDSRRSRRTNRNLTAIRSQDGKAGLESQDDFPDMSTEEFNRRFTLPHLNDLFNVQPMRSTFCTKSSCPLPSETNNSSSRWEDLRKVFVHDDDRVLLKTIKYANPTSSGAECFDEDCNFHHQWVPRAGPRSKIYFDPSEVKAAIVTCGGLCPGLNDVIRQIVLTLDVYGVKRMLGITYGYRGFFEESLEPIVLTRHLVQNIHLAGGSLLGVSRGGAKTSDIVDTLQEKGINMLFVLGGNGTHAGANAIHEEARRRRMKLAVVGVPKTIDNDILLMDKTFGFDTAVEEAQRAINTAYIEANSAYNGIGIVKLMGRQSGFIAMHASLASGQVDVCLIPEVPFALDGGHGVLQHIQHLIEERGKAVICVAEGAGQDLLPTNNGTDPSGNPILGDIGTHLQREIKKYFKAASITVDIKYIDPTYMIRACRANASDGILCAVLGQNAVHGAFAGYSGITVGIANNHYVYLPIPEVISHARNVDPDSRMWHRCLTSTGQPDFIANSS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP019870
EMBL· GenBank· DDBJ
BBN11391.1
EMBL· GenBank· DDBJ
Genomic DNA
LVLJ01004011
EMBL· GenBank· DDBJ
OAE18793.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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