A0A176QEG5 · A0A176QEG5_9MICO
- ProteinPyruvate dehydrogenase E1 component
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids930 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
Catalytic activity
- N6-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + pyruvate + H+ = N6-[(R)-S8-acetyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | magnesium ion binding | |
Molecular Function | pyruvate dehydrogenase (acetyl-transferring) activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePyruvate dehydrogenase E1 component
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micrococcales > Intrasporangiaceae > Janibacter
Accessions
- Primary accessionA0A176QEG5
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 145-315 | Transketolase N-terminal | ||||
Sequence: HPGGGDHIFFQGHASPGMYARAFLEGRLSEDQMDGFRQEKSHEVDGKPFGLPSYPHPRLMPDFWEFPTVSMGLGPMDAIYQAQFNKYLHNRGIKDTSEQHVWAFLGDGEMDEAESRGLLQTAATDELDNLTFVINCNLQRLDGPVRGNGKIIQELEAFFRGAGWNVIKVVW | ||||||
Domain | 503-731 | Pyruvate dehydrogenase E1 component middle | ||||
Sequence: DDAYKQMAKGSGKQEVATTMAWVRLVKDLMREKDFGDRVVPIIPDEARTFGMDSFFPTKKIYNPHGQNYTSVDADLMLAYKESEQGQIIHTGINEAGSVAAFIAAGSSYATHGQPMIPLYIFYSMFGFQRTGDGIWAAADQMTRGFLLGATAGRTTLTGEGLQHADGHSQILAATNPAVVTWDPAFGFEIGHIMRRGLETMYGGDAPQDDPSRNKIYYLTLYNEPYVQP | ||||||
Domain | 745-883 | Transketolase-like C-terminal | ||||
Sequence: GMYLYKKGDAEGLGDTPPRCQLLGSGVGMPWVLEAQELLRKDWGVVADAWSVTSWTELRREAMDCDEQAFLHPEQEKRTPYITTALEPAVGPVVAVSDYMKQVQDQIRPWVPEEFSALGTDGFGFSDTRAAARRFFHVD |
Family and domain databases
Sequence
- Sequence statusComplete
- Length930
- Mass (Da)104,065
- Last updated2016-09-07 v1
- Checksum97BEBD80613251F1
Keywords
- Technical term