A0A176QBZ2 · A0A176QBZ2_9MICO

  • Protein
    Dihydroorotase
  • Gene
    pyrC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site60Zn2+ 1 (UniProtKB | ChEBI)
Binding site62Zn2+ 1 (UniProtKB | ChEBI)
Binding site62-64substrate
Binding site94substrate
Binding site154Zn2+ 1 (UniProtKB | ChEBI)
Binding site154Zn2+ 2 (UniProtKB | ChEBI)
Binding site181Zn2+ 2 (UniProtKB | ChEBI)
Binding site235Zn2+ 2 (UniProtKB | ChEBI)
Binding site281substrate
Active site308
Binding site308Zn2+ 1 (UniProtKB | ChEBI)
Binding site312substrate
Binding site326-327substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionallantoinase activity
Molecular Functiondihydroorotase activity
Molecular Functionzinc ion binding
Biological Process'de novo' UMP biosynthetic process
Biological Processpurine nucleobase catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotase
  • EC number
  • Short names
    DHOase

Gene names

    • Name
      pyrC
    • ORF names
      AWH69_12725

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CD11-4
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Intrasporangiaceae > Janibacter

Accessions

  • Primary accession
    A0A176QBZ2

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain52-240Dihydroorotase bacterial
Domain283-423Amidohydrolase-related

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    439
  • Mass (Da)
    45,405
  • Last updated
    2016-09-07 v1
  • Checksum
    20B82F117E5BBC1F
MSLLVTGARLLDGPAQDLFVEDGRIAALGAQAAEAAQAAEDVEVLDADGLHVLPGLVDLHTHLREPGREDAETIATGSAAAAVGGFTAILAMANTSPVTDTAEAAERVLDLGRAAGLVDVQPIGAVTKGLDGHELAELGLMHRSRAGVTVFSDDGRCVADARVMRRALEYVRAFDGVVSQHSQDPELAGASACCHEGELSGRLGLPGWPAAAEASIIARDAQLALLTGSRVHVAHVSTAEGLEVVRWAKARGARMTAEVTPHHLLLTTDLLSGYDPVYKVNPPLRPDEDVAALREGLADGTIDAVATDHAPHARHDKEHAFVDAAFGMTGLETAFAVVHDVMVRQGSMDLAGLARVMSSAPARIAGLAEHGGELVVGAPAHLALVDPGATVTVDRAATASLSRNTPFHGRTLTGSVVATVLRGALTRTSPDRTTTKVTA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LQZG01000003
EMBL· GenBank· DDBJ
OAB87205.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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