A0A176QAH2 · A0A176QAH2_9MICO

  • Protein
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • Gene
    gpsA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site8-13NAD+ (UniProtKB | ChEBI)
Binding site11NADPH (UniProtKB | ChEBI)
Binding site12NADPH (UniProtKB | ChEBI)
Binding site32NADPH (UniProtKB | ChEBI)
Binding site33NADPH (UniProtKB | ChEBI)
Binding site48NADPH (UniProtKB | ChEBI)
Binding site104NADPH (UniProtKB | ChEBI)
Binding site104sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site104substrate
Binding site134sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site138NAD+ (UniProtKB | ChEBI)
Binding site138NADPH (UniProtKB | ChEBI)
Active site189Proton acceptor
Binding site189sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site242sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site252sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site253NAD+ (UniProtKB | ChEBI)
Binding site253NADPH (UniProtKB | ChEBI)
Binding site253sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site253-254substrate
Binding site254sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site279NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycerol-3-phosphate dehydrogenase (NADP+) activity
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • ORF names
      AWH69_09335

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CD11-4
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Intrasporangiaceae > Janibacter

Accessions

  • Primary accession
    A0A176QAH2

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-158Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain178-318Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    331
  • Mass (Da)
    34,109
  • Last updated
    2016-09-07 v1
  • Checksum
    F3AAF25970E80CAA
MSKVAVFGGGSWGTAFATVLADGGNDVSIWARRPELVAQINRGRNEDYLPDHELPQSISATTDPAEAVDGAEVVVLSVPSQSLRDNLGAWGDVLSQGVVVSLMKGVELGTTKRMSEVISEVGGVPTERIAVVSGPNLAREIVQRQPAATVVACPDQGAADLVAAACATSYFRPYTSTDLVGAEVGGAVKNVIALAVGMAEGMGLGDNTKSSIITRGLAEMTRLGVALGADARTFAGLAGVGDLIATCMSPLSRNHSFGVGLGRGMSVAEVQEHTRQTAEGVKSCSSILDLARAHGVDVPIIEQVSACVHEGTSVPDVVHALLSRARKPETD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LQZG01000003
EMBL· GenBank· DDBJ
OAB86654.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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