A0A175JDR5 · A0A175JDR5_ENTHI

  • Protein
    Phosphatidylethanolamine N-methyltransferase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Lipid metabolism.
Phospholipid metabolism; phosphatidylcholine biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site101-103S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site184-185S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrial membrane
Molecular Functionphosphatidyl-N-methylethanolamine N-methyltransferase activity
Molecular Functionphosphatidylethanolamine N-methyltransferase activity
Biological Processmethylation
Biological Processphosphatidylcholine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylethanolamine N-methyltransferase
  • EC number
  • Short names
    PEAMT
    ; PEMT
  • Alternative names
    • Phospholipid methyltransferase
      (PLMT
      )

Gene names

    • ORF names
      CL6EHI_153710

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • HM1:IMSS clone 6
  • Taxonomic lineage
    Eukaryota > Amoebozoa > Evosea > Archamoebae > Mastigamoebida > Entamoebidae > Entamoeba

Accessions

  • Primary accession
    A0A175JDR5

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, intramembrane, transmembrane.

TypeIDPosition(s)Description
Topological domain1-7Lumenal
Intramembrane8-28Helical
Transmembrane12-30Helical
Topological domain29-40Lumenal
Transmembrane51-70Helical
Transmembrane90-112Helical
Topological domain118-160Lumenal
Transmembrane168-192Helical
Topological domain183-205Cytoplasmic

Keywords

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    205
  • Mass (Da)
    23,486
  • Last updated
    2016-09-07 v1
  • Checksum
    D99470E97D34796B
MFEFVMDQYATLSALFIFASPAVWNTLAHIEYFTHKISQLFHGNKENGFRFVMCIIISMQIIRNIFFYIACTSAVPMIPAIDSFLSSIPTLVNIVAIPIQIFGWVLSISSFYRLGFKGTYEGDCFGFLFDEMITSFPFGFVPHPMYFGGALLFISSALYYYSSTGLILSIWSIVVYCIFSYLVEQPLTILIYSNKKTQHDEKKEE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BDEQ01000001
EMBL· GenBank· DDBJ
GAT91624.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp