A0A174QZG7 · A0A174QZG7_PHOVU

Function

function

Bifunctional aspartate kinase and homoserine dehydrogenase that catalyzes the first and the third steps toward the synthesis of lysine, methionine and threonine from aspartate.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionaspartate kinase activity
Molecular FunctionATP binding
Molecular Functionhomoserine dehydrogenase activity
Molecular Functionmetal ion binding
Molecular FunctionNADP binding
Biological Processhomoserine biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate
Biological Processmethionine biosynthetic process
Biological Processphosphorylation
Biological Processthreonine biosynthetic process

Keywords

Enzyme and pathway databases

    • UPA00034UER00015
    • UPA00050UER00063
    • UPA00051UER00462

Names & Taxonomy

Protein names

  • Submitted names
    • Bifunctional aspartate kinase/homoserine dehydrogenase I
      (EC:1.1.1.3
      , EC:2.7.2.4
      )
    • Bifunctional aspartokinase I/homoserine dehydrogenase I
    • Bifunctional aspartokinase/homoserine dehydrogenase 1

Gene names

    • Name
      thrA
    • ORF names
      BHV80_05545
      , DWX04_12475
      , DXC16_10165
      , DXD46_07480
      , EH214_01322
      , ERS852457_03954
      , F9Z94_18125
      , GAS29_14290
      , GAY01_16040
      , GAY17_14395
      , GAY76_10365
      , GAZ76_15600
      , GAZ92_13285
      , HKQ49_14330
      , HKQ51_04655
      , HUV05_09225
      , L0N01_06150
      , LI282_07595
      , RVH43_14930
      , VIC01_03542

Organism names

  • Taxonomic identifier
  • Strains
    • 2789STDY5834842
    • 42_262
    • AF18-14
    • OM08-13BH
    • TM05-16
  • Taxonomic lineage
    Bacteria > Bacteroidota > Bacteroidia > Bacteroidales > Bacteroidaceae > Phocaeicola

Accessions

  • Primary accession
    A0A174QZG7

Proteomes

Subcellular Location

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain395-468ACT

Sequence similarities

Belongs to the aspartokinase family.
In the C-terminal section; belongs to the homoserine dehydrogenase family.
In the N-terminal section; belongs to the aspartokinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    810
  • Mass (Da)
    88,621
  • Last updated
    2016-09-07 v1
  • Checksum
    5D3B98E75B0C6E27
MKVMKFGGTSVGSVNSILSVKQIVEAVEEPVIVVVSALGGITDKLINTSQMAANGDSAYEKEYREIVNRHIEMVYTVIPAGNERTVLLDKVNELLSELKDIFQGIYLIKDLSSKTSATIVSYGERLSSIIVASLIKGAVWYDSRNFIKTEKKHAKHILDSELTTRLVKETFQKLPEVALVPGFISTDKNSGEVTNLGRGGSDYTASVIAAALNADSLEIWTDVDGFMTADPRVISTAYTINELSYVEAMELCNFGAKVVYPPTIYPVCHKNIPILIKNTFNPQGEGTIIKQEVNSGSKAIKGISSINDTSLITVTGLGMVGVIGVNFRIFKALAQNGISVFMVSQASSENSTSIGVRNQDAALACEVLNEEFSKEIEMGEISPVVAEMNLATIAIVGENMKHTPGIAGKLFGTLGRNGISVIACAQGASETNISFVVESKSLRKSLNVIHDSFFLSEYQVLNLFICGTGTVGGSLIEQIRCQQQKLMQERGLKLKVVGIADGHHALFTRAGVDLSHYKEELAEKGMPSSTQVLHDEIIGMNIFNSVFVDCTASAEVASLYKDFLMNNISVVAANKIAASSEYSVYSELKQIARRRGVKFLFETNVGAGLPIINTINDLINSGDKILKIEAVLSGTLNYIFNKISADIPFSKTIKMAQEERYSEPDPRIDLSGKDVIRKLVILAREAGYKLEQEDVEKHLFVPNDFFEGPLEEFWKKVPSLDADFESRRQKLEDENKRWRFVAKLEDGKGSVSLQEVDSKHPFYGLEGSNNIILLTTERYKEYPMMIQGYGAGASVTAAGVFADIMSIANI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CYZI01000045
EMBL· GenBank· DDBJ
CUP36198.1
EMBL· GenBank· DDBJ
Genomic DNA
WCZM01000025
EMBL· GenBank· DDBJ
KAB3566933.1
EMBL· GenBank· DDBJ
Genomic DNA
WCWW01000033
EMBL· GenBank· DDBJ
KAB3854493.1
EMBL· GenBank· DDBJ
Genomic DNA
WCIF01000026
EMBL· GenBank· DDBJ
KAB5434352.1
EMBL· GenBank· DDBJ
Genomic DNA
WDAX01000021
EMBL· GenBank· DDBJ
KAB6573533.1
EMBL· GenBank· DDBJ
Genomic DNA
WDAG01000020
EMBL· GenBank· DDBJ
KAB6657717.1
EMBL· GenBank· DDBJ
Genomic DNA
WCZY01000018
EMBL· GenBank· DDBJ
KAB6691350.1
EMBL· GenBank· DDBJ
Genomic DNA
WCZV01000019
EMBL· GenBank· DDBJ
KAB6698464.1
EMBL· GenBank· DDBJ
Genomic DNA
JAJCQG010000019
EMBL· GenBank· DDBJ
MCB7280901.1
EMBL· GenBank· DDBJ
Genomic DNA
JAKNGO010000010
EMBL· GenBank· DDBJ
MCG4688193.1
EMBL· GenBank· DDBJ
Genomic DNA
JAWDET010000006
EMBL· GenBank· DDBJ
MDU0241885.1
EMBL· GenBank· DDBJ
Genomic DNA
JABDSB010000069
EMBL· GenBank· DDBJ
NMW78944.1
EMBL· GenBank· DDBJ
Genomic DNA
JABDSD010000056
EMBL· GenBank· DDBJ
NMX07193.1
EMBL· GenBank· DDBJ
Genomic DNA
JABWDJ010000029
EMBL· GenBank· DDBJ
NVB73697.1
EMBL· GenBank· DDBJ
Genomic DNA
MNQV01000126
EMBL· GenBank· DDBJ
OKZ52172.1
EMBL· GenBank· DDBJ
Genomic DNA
CP043529
EMBL· GenBank· DDBJ
QEW37938.1
EMBL· GenBank· DDBJ
Genomic DNA
QSPP01000015
EMBL· GenBank· DDBJ
RGJ89101.1
EMBL· GenBank· DDBJ
Genomic DNA
QSTG01000015
EMBL· GenBank· DDBJ
RGM43925.1
EMBL· GenBank· DDBJ
Genomic DNA
QRXI01000015
EMBL· GenBank· DDBJ
RGT92296.1
EMBL· GenBank· DDBJ
Genomic DNA
RWHZ01000012
EMBL· GenBank· DDBJ
TSE49455.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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