A0A174QZG7 · A0A174QZG7_PHOVU
- ProteinBifunctional aspartate kinase/homoserine dehydrogenase I
- GenethrA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids810 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Bifunctional aspartate kinase and homoserine dehydrogenase that catalyzes the first and the third steps toward the synthesis of lysine, methionine and threonine from aspartate.
Catalytic activity
- L-aspartate + ATP = 4-phospho-L-aspartate + ADPThis reaction proceeds in the forward direction.
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | aspartate kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | homoserine dehydrogenase activity | |
Molecular Function | metal ion binding | |
Molecular Function | NADP binding | |
Biological Process | homoserine biosynthetic process | |
Biological Process | lysine biosynthetic process via diaminopimelate | |
Biological Process | methionine biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | threonine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Bacteroidota > Bacteroidia > Bacteroidales > Bacteroidaceae > Phocaeicola
Accessions
- Primary accessionA0A174QZG7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 395-468 | ACT | |||
Sequence similarities
Belongs to the aspartokinase family.
In the C-terminal section; belongs to the homoserine dehydrogenase family.
In the N-terminal section; belongs to the aspartokinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length810
- Mass (Da)88,621
- Last updated2016-09-07 v1
- Checksum5D3B98E75B0C6E27
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CYZI01000045 EMBL· GenBank· DDBJ | CUP36198.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WCZM01000025 EMBL· GenBank· DDBJ | KAB3566933.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WCWW01000033 EMBL· GenBank· DDBJ | KAB3854493.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WCIF01000026 EMBL· GenBank· DDBJ | KAB5434352.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WDAX01000021 EMBL· GenBank· DDBJ | KAB6573533.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WDAG01000020 EMBL· GenBank· DDBJ | KAB6657717.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WCZY01000018 EMBL· GenBank· DDBJ | KAB6691350.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WCZV01000019 EMBL· GenBank· DDBJ | KAB6698464.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAJCQG010000019 EMBL· GenBank· DDBJ | MCB7280901.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAKNGO010000010 EMBL· GenBank· DDBJ | MCG4688193.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAWDET010000006 EMBL· GenBank· DDBJ | MDU0241885.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JABDSB010000069 EMBL· GenBank· DDBJ | NMW78944.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JABDSD010000056 EMBL· GenBank· DDBJ | NMX07193.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JABWDJ010000029 EMBL· GenBank· DDBJ | NVB73697.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MNQV01000126 EMBL· GenBank· DDBJ | OKZ52172.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP043529 EMBL· GenBank· DDBJ | QEW37938.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QSPP01000015 EMBL· GenBank· DDBJ | RGJ89101.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QSTG01000015 EMBL· GenBank· DDBJ | RGM43925.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QRXI01000015 EMBL· GenBank· DDBJ | RGT92296.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RWHZ01000012 EMBL· GenBank· DDBJ | TSE49455.1 EMBL· GenBank· DDBJ | Genomic DNA |