A0A173WVZ0 · A0A173WVZ0_9BIFI
- Protein3-isopropylmalate dehydratase large subunit
- GeneleuC
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids467 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Catalytic activity
- (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway
Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2-methylisocitrate dehydratase activity | |
Molecular Function | 3-isopropylmalate dehydratase activity | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | metal ion binding | |
Biological Process | L-leucine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-isopropylmalate dehydratase large subunit
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Bifidobacteriales > Bifidobacteriaceae > Bifidobacterium
Accessions
- Primary accessionA0A173WVZ0
Proteomes
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-459 | Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha | ||||
Sequence: EKVWADHLVRKGSDGAPDLLYIDLMLMHEVTSPQAFEGLRLAGRKPRHLDQLIATEDHNTPTADIDRPNPDKISALQLSTLEKNCKDFGVRLCPLGDADQGVVHAFAPVLGLTQPGMTIVCGDSHTSTHGAFGAMAIGIGTSEVEHVMATQTLSLKPFKTMAVNIEGELPKGVTAKDIILAIIAKIGTGGGQGHVIEYRGEAIKKLSMDARMTICNMSIEAGARAGMIAPDEVTFEYLKGRPHAPEGEMWDKAIEYWKTLKTDDDAVFDKEVTIKAEDLEPYVTWGTNPGQGIKISGVVPDPASFNDETERTAAERAIAYMGLTPGMRIKDIAVDTVFIGSCTNGRLEDLRVAASIMKGHHKAENIHRVLVVPASSRVRLQAEKEGLDKIFKDFGAEWRNAGCSMCLGMNPDKMVARERSISTSNRNFEGRQGKGSRTHLASPAVAAATAIRG |
Sequence similarities
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length467
- Mass (Da)50,366
- Last updated2016-09-07 v1
- Checksum9F51165092CF1371
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BSTY01000002 EMBL· GenBank· DDBJ | GLZ82880.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAHXEK010000004 EMBL· GenBank· DDBJ | MCB4899093.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JARJNE010000002 EMBL· GenBank· DDBJ | MDF4091351.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QSWD01000001 EMBL· GenBank· DDBJ | RGP04518.1 EMBL· GenBank· DDBJ | Genomic DNA |