A0A173ADG5 · A0A173ADG5_HUMAN
- ProteinHLA class II histocompatibility antigen DQ alpha chain
- GeneHLA-DQA1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids255 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endosome membrane | |
Cellular Component | lysosomal membrane | |
Cellular Component | MHC class II protein complex | |
Biological Process | adaptive immune response | |
Biological Process | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A173ADG5
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endosome membrane ; Single-pass type I membrane protein
Lysosome membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 222-240 | Helical | ||||
Sequence: ALGLSVGLMGIVVGTVFII |
Keywords
- Cellular component
Disease & Variants
Organism-specific databases
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MILNKALLLGALALTTVMSPCGG | ||||||
Chain | PRO_5015052223 | 24-255 | ||||
Sequence: EDIVADHVASCGVNLYQFYGPSGQYTHEFDGDEQFYVDLERKETAWRWPEFSKFGGFDPQGALRNMAVAKHNLNIMIKRYNSTAATNEVPEVTVFSKSPVTLGQPNTLICLVDNIFPPVVNITWLSNGQSVTEGVSETSFLSKSDHSFFKISYLTFLPSADEIYDCKVEHWGLDQPLLKHWEPEIPAPMSELTETVVCALGLSVGLMGIVVGTVFIIQGLRSVGASRHQGPL | ||||||
Disulfide bond | 133↔189 | |||||
Sequence: CLVDNIFPPVVNITWLSNGQSVTEGVSETSFLSKSDHSFFKISYLTFLPSADEIYDC | ||||||
Glycosylation | 144 | N-acetyl-D-glucosamine | ||||
Sequence: N | ||||||
Glycosylation | 144 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 113-193 | Ig-like | ||||
Sequence: PEVTVFSKSPVTLGQPNTLICLVDNIFPPVVNITWLSNGQSVTEGVSETSFLSKSDHSFFKISYLTFLPSADEIYDCKVEH |
Sequence similarities
Belongs to the MHC class II family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length255
- Mass (Da)28,000
- Last updated2016-09-07 v1
- ChecksumBE0CF3CED76CBAA3
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KU319341 EMBL· GenBank· DDBJ | ANG08756.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU319342 EMBL· GenBank· DDBJ | ANG08757.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU319343 EMBL· GenBank· DDBJ | ANG08758.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU319344 EMBL· GenBank· DDBJ | ANG08759.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY057361 EMBL· GenBank· DDBJ | APO40933.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY172886 EMBL· GenBank· DDBJ | APO40934.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC257816 EMBL· GenBank· DDBJ | BBD34134.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC257817 EMBL· GenBank· DDBJ | BBD34135.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC257818 EMBL· GenBank· DDBJ | BBD34136.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC257819 EMBL· GenBank· DDBJ | BBD34137.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC257820 EMBL· GenBank· DDBJ | BBD34138.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HG993078 EMBL· GenBank· DDBJ | CAE6990116.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH892059 EMBL· GenBank· DDBJ | QCF28407.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH892064 EMBL· GenBank· DDBJ | QCF28412.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK448289 EMBL· GenBank· DDBJ | QCY59244.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK610123 EMBL· GenBank· DDBJ | QCY59253.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK501650 EMBL· GenBank· DDBJ | QDB65110.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK392190 EMBL· GenBank· DDBJ | QEG47625.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK392193 EMBL· GenBank· DDBJ | QEG47628.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN206022 EMBL· GenBank· DDBJ | QFG58551.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN153777 EMBL· GenBank· DDBJ | QFQ66437.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN889865 EMBL· GenBank· DDBJ | QHR76760.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN889867 EMBL· GenBank· DDBJ | QHR76762.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN208443 EMBL· GenBank· DDBJ | QIB00608.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481210 EMBL· GenBank· DDBJ | QJX19982.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW344052 EMBL· GenBank· DDBJ | QWV59128.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MZ171324 EMBL· GenBank· DDBJ | QXL99763.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW147020 EMBL· GenBank· DDBJ | QXU63127.1 EMBL· GenBank· DDBJ | Genomic DNA |