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A0A172YYU0 · A0A172YYU0_9PSED

  • Protein
    NADPH-dependent 7-cyano-7-deazaguanine reductase
  • Gene
    queF
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).

Catalytic activity

Pathway

tRNA modification; tRNA-queuosine biosynthesis.

Features

Showing features for binding site, active site.

127620406080100120140160180200220240260
Type
IDPosition(s)Description
Binding site83-85substrate
Binding site85-86NADPH (UniProtKB | ChEBI)
Active site184Thioimide intermediate
Active site191Proton donor
Binding site223-224substrate
Binding site252-253NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionpreQ1 synthase activity
Biological Processqueuosine biosynthetic process
Biological ProcesstRNA modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADPH-dependent 7-cyano-7-deazaguanine reductase
  • EC number
  • Alternative names
    • 7-cyano-7-carbaguanine reductase
    • NADPH-dependent nitrile oxidoreductase
    • PreQ(0) reductase

Gene names

    • Name
      queF
    • ORF names
      A7J50_1703

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • PAMC 27494
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A172YYU0

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain16-126NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal

Sequence similarities

Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    276
  • Mass (Da)
    30,886
  • Last updated
    2016-09-07 v1
  • MD5 Checksum
    4BDEF18B6ED62388D3E5425C9B509228
MHPAAEHSPLGKSSEYISTYTPSLLFPIPRAAKWAELGLSAETLPYKGVDFWNCFELSWLLPSGKPVVAIGEFSIPADSPNIIESKSFKLYLNSLNQTAFADTASLEATLRTDLSAAAGKPVSVRIRRLAEVEAEGVQALPGVCIDDLDISVSNYEHPRPELLRCDDSRIVEESVHSHLLKSNCPVTSQPDWGSVAVQYRGSALDHASLLEYIVSFRQHSDFHEQCVERIFLDLQRLLKPEKLTVYARYVRRGGLDINPYRSTEDMPFQNVRLARQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP015600
EMBL· GenBank· DDBJ
ANF85126.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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