A0A172YU84 · A0A172YU84_9PSED

  • Protein
    Phosphoribosyl-AMP cyclohydrolase
  • Gene
    hisI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site77Mg2+ (UniProtKB | ChEBI)
Binding site78Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site79Mg2+ (UniProtKB | ChEBI)
Binding site81Mg2+ (UniProtKB | ChEBI)
Binding site95Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site102Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmagnesium ion binding
Molecular Functionphosphoribosyl-AMP cyclohydrolase activity
Molecular Functionzinc ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosyl-AMP cyclohydrolase
  • EC number
  • Short names
    PRA-CH

Gene names

    • Name
      hisI
    • ORF names
      A7J50_0375

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • PAMC 27494
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A172YU84

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain30-104Phosphoribosyl-AMP cyclohydrolase

Sequence similarities

Belongs to the PRA-CH family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    130
  • Mass (Da)
    15,030
  • Last updated
    2016-09-07 v1
  • Checksum
    5453895706567374
MKDWLDEIKWDSDGLVPAIAQDYKTGRVLMMAWMNREALSLTATEQRAIYWSRSRGKLWRKGEESGHVQTLHEMRIDCDADVVILKVEQIGDIACHTGRHSCFYRVFENGEWKVVEPVLKDPHAIYSAGH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP015600
EMBL· GenBank· DDBJ
ANF83823.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp