A0A172YES9 · A0A172YES9_9GAMM

  • Protein
    5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
  • Gene
    mtnN
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site18Proton acceptor
Binding site84substrate
Binding site159substrate
Binding site180-181substrate
Active site204Proton donor

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionadenosylhomocysteine nucleosidase activity
Molecular Functionmethylthioadenosine nucleosidase activity
Biological ProcessL-methionine salvage from methylthioadenosine
Biological ProcessL-methionine salvage from S-adenosylmethionine
Biological Processnucleoside catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
  • EC number
  • Short names
    MTA/SAH nucleosidase
    ; MTAN
  • Alternative names
    • 5'-deoxyadenosine nucleosidase
      (DOA nucleosidase
      ; dAdo nucleosidase
      )
    • 5'-methylthioadenosine nucleosidase
      (MTA nucleosidase
      )
    • S-adenosylhomocysteine nucleosidase
      (AdoHcy nucleosidase
      ; SAH nucleosidase
      ; SRH nucleosidase
      )

Gene names

    • Name
      mtnN
    • ORF names
      A5892_09710

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • IHB B 13600
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Oceanospirillales > Halomonadaceae > Halotalea

Accessions

  • Primary accession
    A0A172YES9

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-234Nucleoside phosphorylase

Sequence similarities

Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    238
  • Mass (Da)
    24,756
  • Last updated
    2016-09-07 v1
  • MD5 Checksum
    992F99FAD6075BAE844BF98698E0F346
MAASSGVQVALIGAMAQEVDALLTHLERGERLEHGGSTFHLGRLRGIEVVVLESGIGKVNAAIATTLAFERFAPRAVINVGSAGGFGDRLAIGDVVISSEVCHHDVDVTPFGYALGQVPGMPARFAADPRLVALAREALEGLDGITAHEGLIGSGDVFVAGGAVVASLRSRFPEMIAAEMEAAAVAQTCHRHGCPFVVTRAVSDLPEREANSVDFETFLGIAAANSARMVASMLERLD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP015243
EMBL· GenBank· DDBJ
ANF57707.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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