A0A172YES9 · A0A172YES9_9GAMM
- Protein5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
- GenemtnN
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids238 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
Catalytic activity
- 5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 18 | Proton acceptor | |||
Binding site | 84 | substrate | |||
Binding site | 159 | substrate | |||
Binding site | 180-181 | substrate | |||
Active site | 204 | Proton donor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | adenosylhomocysteine nucleosidase activity | |
Molecular Function | methylthioadenosine nucleosidase activity | |
Biological Process | L-methionine salvage from methylthioadenosine | |
Biological Process | L-methionine salvage from S-adenosylmethionine | |
Biological Process | nucleoside catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
- EC number
- Short namesMTA/SAH nucleosidase ; MTAN
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Oceanospirillales > Halomonadaceae > Halotalea
Accessions
- Primary accessionA0A172YES9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length238
- Mass (Da)24,756
- Last updated2016-09-07 v1
- MD5 Checksum992F99FAD6075BAE844BF98698E0F346
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP015243 EMBL· GenBank· DDBJ | ANF57707.1 EMBL· GenBank· DDBJ | Genomic DNA |