A0A172YAM3 · A0A172YAM3_9GAMM
- ProteinFructose-1,6-bisphosphate aldolase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids354 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
Catalytic activity
- beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 Zn2+ ions per subunit. One is catalytic and the other provides a structural contribution.
Note: One is catalytic and the other provides a structural contribution.
Pathway
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 83 | Proton donor | |||
Binding site | 84 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 105 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 142 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 198 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 199 | dihydroxyacetone phosphate (UniProtKB | ChEBI) | |||
Binding site | 232 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 233-235 | dihydroxyacetone phosphate (UniProtKB | ChEBI) | |||
Binding site | 275-278 | dihydroxyacetone phosphate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | fructose-bisphosphate aldolase activity | |
Molecular Function | zinc ion binding | |
Biological Process | glycolytic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFructose-1,6-bisphosphate aldolase
- EC number
- Short namesFBP aldolase
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Oceanospirillales > Halomonadaceae > Halotalea
Accessions
- Primary accessionA0A172YAM3
Proteomes
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length354
- Mass (Da)38,383
- Last updated2016-09-07 v1
- MD5 Checksum3229BF06E69770651546A4CABE193E80
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP015243 EMBL· GenBank· DDBJ | ANF56176.1 EMBL· GenBank· DDBJ | Genomic DNA |