A0A172YAM3 · A0A172YAM3_9GAMM

  • Protein
    Fructose-1,6-bisphosphate aldolase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit. One is catalytic and the other provides a structural contribution.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: One is catalytic and the other provides a structural contribution.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site83Proton donor
Binding site84Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site105Zn2+ 2 (UniProtKB | ChEBI)
Binding site142Zn2+ 2 (UniProtKB | ChEBI)
Binding site198Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site199dihydroxyacetone phosphate (UniProtKB | ChEBI)
Binding site232Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site233-235dihydroxyacetone phosphate (UniProtKB | ChEBI)
Binding site275-278dihydroxyacetone phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionfructose-bisphosphate aldolase activity
Molecular Functionzinc ion binding
Biological Processglycolytic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fructose-1,6-bisphosphate aldolase
  • EC number
  • Short names
    FBP aldolase

Gene names

    • ORF names
      A5892_00775

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • IHB B 13600
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Oceanospirillales > Halomonadaceae > Halotalea

Accessions

  • Primary accession
    A0A172YAM3

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the class II fructose-bisphosphate aldolase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    354
  • Mass (Da)
    38,383
  • Last updated
    2016-09-07 v1
  • MD5 Checksum
    3229BF06E69770651546A4CABE193E80
MALISMRQLLDHAAEHGYGVPAFNVNNLEQMRAIMEAADATDSPVIVQASAGARKYAGAPFLRHLILAAVEEFPHIPVVMHQDHGTSPAVCQRSIQLGFSSVMMDGSLGEDGKTPTDYDYNVDVTRRTVEMAHACGVSVEGELGCLGSLETGMAGEEDGIGAEGVLDHSQLLTDPEEAADFVRATQVDALAIAIGTSHGAYKFTRPPTGDTLSIQRIKEIHARLPDTHLVMHGSSSVPQEWLEVINRFGGEIDETYGVPVDEIVEGIKHGVRKVNIDTDLRLASTGAIRRFMAEHPSEFDPRKYLAETVKAMRDIAAARYEAFGTAGQAAKIKAISLEKMAQRYTSGELRPNLY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP015243
EMBL· GenBank· DDBJ
ANF56176.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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