A0A172YA69 · A0A172YA69_9GAMM

  • Protein
    Imidazole glycerol phosphate synthase subunit HisH
  • Gene
    hisH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site82Nucleophile
Active site192
Active site194

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionglutaminase activity
Molecular Functionimidazoleglycerol-phosphate synthase activity
Molecular Functionlyase activity
Biological Processglutamine metabolic process
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Imidazole glycerol phosphate synthase subunit HisH
  • EC number
  • Alternative names
    • IGP synthase glutaminase subunit
      (EC:3.5.1.2
      ) . EC:3.5.1.2 (UniProtKB | ENZYME | Rhea)
    • IGP synthase subunit HisH
    • ImGP synthase subunit HisH
      (IGPS subunit HisH
      )

Gene names

    • Name
      hisH
    • ORF names
      A5892_00420

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • IHB B 13600
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Oceanospirillales > Halomonadaceae > Halotalea

Accessions

  • Primary accession
    A0A172YA69

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterodimer of HisH and HisF.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-208Glutamine amidotransferase

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    212
  • Mass (Da)
    23,387
  • Last updated
    2016-09-07 v1
  • Checksum
    B138E995D01F8508
MTIAVIDYGMGNLHSVAKALEHVTEERIAITRDPRAIKGATRVVLPGQGAIRDCIGELERTELTGLVKTLLADGDKPLLGICVGQQMLMEKSEENGGVRCLGYLEGEVKRFPADMVEHGERLKVPHMGWNQVEQHHMHPLWEGIPTGDRFYFVHSYYVAASHDAEVFGTVRYGDVVAHVATGRDATFAVQFHPEKSAAMGLRLLANFVAWAP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP015243
EMBL· GenBank· DDBJ
ANF56119.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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