A0A172RNH8 · A0A172RNH8_CANLF
- ProteinCytochrome c oxidase subunit 1
- GeneCOX1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids514 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2O
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | oxidative phosphorylation |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis
Accessions
- Primary accessionA0A172RNH8
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 18-37 | Helical | ||||
Sequence: LYLLFGAWAGMVGTALSLLI | ||||||
Transmembrane | 57-83 | Helical | ||||
Sequence: IVTAHAFVMIFFMVMPIMIGGFGNWLV | ||||||
Transmembrane | 104-128 | Helical | ||||
Sequence: LLPPSFLLLLASSMVEAGAGTGWTV | ||||||
Transmembrane | 148-171 | Helical | ||||
Sequence: FSLHLAGVSSILGAINFITTIINM | ||||||
Transmembrane | 183-210 | Helical | ||||
Sequence: LFVWSVLITAVLLLLSLPVLAAGITMLL | ||||||
Transmembrane | 243-261 | Helical | ||||
Sequence: VYILILPGFGMISHIVTYY | ||||||
Transmembrane | 268-291 | Helical | ||||
Sequence: FGYMGMVWAMMSIGFLGFIVWAHH | ||||||
Transmembrane | 303-325 | Helical | ||||
Sequence: AYFTSATMIIAIPTGVKVFSWLA | ||||||
Transmembrane | 337-359 | Helical | ||||
Sequence: AMLWALGFIFLFTVGGLTGIVLA | ||||||
Transmembrane | 379-400 | Helical | ||||
Sequence: YVLSMGAVFAIMGGFAHWFPLF | ||||||
Transmembrane | 412-433 | Helical | ||||
Sequence: IHFTIMFVGVNMTFFPQHFLGL | ||||||
Transmembrane | 453-476 | Helical | ||||
Sequence: VSSMGSFISLTAVMLMIFMIWEAF |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-514 | Cytochrome oxidase subunit I profile | ||||
Sequence: MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFAHWFPLFSGYTLNDTWAKIHFTIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTTWNTVSSMGSFISLTAVMLMIFMIWEAFASKREVAMVKLTTTNIEWLHGCPPPYHTFEEPTYVIQK |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length514
- Mass (Da)57,038
- Last updated2016-09-07 v1
- Checksum44D2B3E8EEAC516F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KU290931 EMBL· GenBank· DDBJ | ANE18123.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290932 EMBL· GenBank· DDBJ | ANE18134.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290933 EMBL· GenBank· DDBJ | ANE18147.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290935 EMBL· GenBank· DDBJ | ANE18173.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290938 EMBL· GenBank· DDBJ | ANE18212.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290939 EMBL· GenBank· DDBJ | ANE18225.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290944 EMBL· GenBank· DDBJ | ANE18290.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290945 EMBL· GenBank· DDBJ | ANE18303.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290947 EMBL· GenBank· DDBJ | ANE18328.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290948 EMBL· GenBank· DDBJ | ANE18341.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290952 EMBL· GenBank· DDBJ | ANE18393.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290972 EMBL· GenBank· DDBJ | ANE18653.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290985 EMBL· GenBank· DDBJ | ANE18822.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU291000 EMBL· GenBank· DDBJ | ANE19017.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU291016 EMBL· GenBank· DDBJ | ANE19225.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU291036 EMBL· GenBank· DDBJ | ANE19484.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU291067 EMBL· GenBank· DDBJ | ANE19887.1 EMBL· GenBank· DDBJ | Genomic DNA |