A0A172RNH8 · A0A172RNH8_CANLF

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • 756T
    • 757T
    • 758T
    • 759T
    • 761T1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis

Accessions

  • Primary accession
    A0A172RNH8

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane18-37Helical
Transmembrane57-83Helical
Transmembrane104-128Helical
Transmembrane148-171Helical
Transmembrane183-210Helical
Transmembrane243-261Helical
Transmembrane268-291Helical
Transmembrane303-325Helical
Transmembrane337-359Helical
Transmembrane379-400Helical
Transmembrane412-433Helical
Transmembrane453-476Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-514Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    514
  • Mass (Da)
    57,038
  • Last updated
    2016-09-07 v1
  • Checksum
    44D2B3E8EEAC516F
MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFAHWFPLFSGYTLNDTWAKIHFTIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTTWNTVSSMGSFISLTAVMLMIFMIWEAFASKREVAMVKLTTTNIEWLHGCPPPYHTFEEPTYVIQK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KU290931
EMBL· GenBank· DDBJ
ANE18123.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290932
EMBL· GenBank· DDBJ
ANE18134.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290933
EMBL· GenBank· DDBJ
ANE18147.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290935
EMBL· GenBank· DDBJ
ANE18173.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290938
EMBL· GenBank· DDBJ
ANE18212.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290939
EMBL· GenBank· DDBJ
ANE18225.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290944
EMBL· GenBank· DDBJ
ANE18290.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290945
EMBL· GenBank· DDBJ
ANE18303.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290947
EMBL· GenBank· DDBJ
ANE18328.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290948
EMBL· GenBank· DDBJ
ANE18341.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290952
EMBL· GenBank· DDBJ
ANE18393.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290972
EMBL· GenBank· DDBJ
ANE18653.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290985
EMBL· GenBank· DDBJ
ANE18822.1
EMBL· GenBank· DDBJ
Genomic DNA
KU291000
EMBL· GenBank· DDBJ
ANE19017.1
EMBL· GenBank· DDBJ
Genomic DNA
KU291016
EMBL· GenBank· DDBJ
ANE19225.1
EMBL· GenBank· DDBJ
Genomic DNA
KU291036
EMBL· GenBank· DDBJ
ANE19484.1
EMBL· GenBank· DDBJ
Genomic DNA
KU291067
EMBL· GenBank· DDBJ
ANE19887.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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