A0A172R7K2 · A0A172R7K2_CANLF
- ProteinNADH-ubiquinone oxidoreductase chain 5
- GeneND5
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids606 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respirasome | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Biological Process | ATP synthesis coupled electron transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 5
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis
Accessions
- Primary accessionA0A172R7K2
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-27 | Helical | ||||
Sequence: SCMITALVILTLPIIMSSTKLY | ||||||
Transmembrane | 39-58 | Helical | ||||
Sequence: ATSYAFMISMIPTMMFIYSG | ||||||
Transmembrane | 84-105 | Helical | ||||
Sequence: YFSMIFVPVALFVTWSIMEFSM | ||||||
Transmembrane | 117-134 | Helical | ||||
Sequence: FFKYLLLFLITMMVLVTA | ||||||
Transmembrane | 140-160 | Helical | ||||
Sequence: LFIGWEGVGIMSFLLIGWWYG | ||||||
Transmembrane | 172-191 | Helical | ||||
Sequence: VLYNRIGDVGFIMTMAWFLL | ||||||
Transmembrane | 245-263 | Helical | ||||
Sequence: ALLHSSTMVVAGVFLLIRF | ||||||
Transmembrane | 275-294 | Helical | ||||
Sequence: TLTLCLGAINTLFTAICALT | ||||||
Transmembrane | 362-386 | Helical | ||||
Sequence: LFKVLPFTTTSLIIGSLALTGMPFL | ||||||
Transmembrane | 406-432 | Helical | ||||
Sequence: AWALLITLVATSLTAAYSTRIMFFALL | ||||||
Transmembrane | 453-472 | Helical | ||||
Sequence: SIKRLLIGSVFAGYIISHSI | ||||||
Transmembrane | 484-502 | Helical | ||||
Sequence: HYLKMTALAVTTLGFILAL | ||||||
Transmembrane | 586-605 | Helical | ||||
Sequence: LYFLSFMLTMILSLLILNYH |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 68-118 | NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal | ||||
Sequence: WMTIQTMKLSMSFKLDYFSMIFVPVALFVTWSIMEFSMWYMHSDPYINRFF | ||||||
Domain | 134-418 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | ||||
Sequence: ANNMFQLFIGWEGVGIMSFLLIGWWYGRTDANTAALQAVLYNRIGDVGFIMTMAWFLLNLNTWDLQQIFITTNDNFNLPLLGLLLAATGKSAQFGLHPWLPSAMEGPTPASALLHSSTMVVAGVFLLIRFHPLMEHNQTIQTLTLCLGAINTLFTAICALTQNDIKKIVAFSTSSQLGLMMVTIGINQPYLAFLHICTHAFFKAMLFMCSGSVIHSLNDEQDIRKMGGLFKVLPFTTTSLIIGSLALTGMPFLTGFYSKDLIIESANTSNTNAWALLITLVATSL | ||||||
Domain | 422-601 | NADH dehydrogenase subunit 5 C-terminal | ||||
Sequence: YSTRIMFFALLGQPRFSPMILINENNPLLINSIKRLLIGSVFAGYIISHSITPTTIPQMTMPHYLKMTALAVTTLGFILALELNLTTQGLKFNYPSNYFKFSSLLGYYPTIMHRLTPKTSLTISQKSASMLLDSIWLENILPKSISYFQMKSSTLISNQKGLIKLYFLSFMLTMILSLLI |
Sequence similarities
Belongs to the complex I subunit 5 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length606
- Mass (Da)68,360
- Last updated2016-09-07 v1
- Checksum0721751A773BDCFD
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KU290432 EMBL· GenBank· DDBJ | ANE11651.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290434 EMBL· GenBank· DDBJ | ANE11677.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290436 EMBL· GenBank· DDBJ | ANE11703.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290438 EMBL· GenBank· DDBJ | ANE11729.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290441 EMBL· GenBank· DDBJ | ANE11768.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290443 EMBL· GenBank· DDBJ | ANE11794.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290445 EMBL· GenBank· DDBJ | ANE11820.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290473 EMBL· GenBank· DDBJ | ANE12184.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290481 EMBL· GenBank· DDBJ | ANE12288.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290483 EMBL· GenBank· DDBJ | ANE12314.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290485 EMBL· GenBank· DDBJ | ANE12340.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290487 EMBL· GenBank· DDBJ | ANE12366.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290489 EMBL· GenBank· DDBJ | ANE12392.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290491 EMBL· GenBank· DDBJ | ANE12418.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290493 EMBL· GenBank· DDBJ | ANE12444.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290495 EMBL· GenBank· DDBJ | ANE12470.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290509 EMBL· GenBank· DDBJ | ANE12652.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290513 EMBL· GenBank· DDBJ | ANE12704.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290515 EMBL· GenBank· DDBJ | ANE12730.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290517 EMBL· GenBank· DDBJ | ANE12756.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290583 EMBL· GenBank· DDBJ | ANE13612.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290600 EMBL· GenBank· DDBJ | ANE13833.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290613 EMBL· GenBank· DDBJ | ANE14002.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290631 EMBL· GenBank· DDBJ | ANE14236.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290645 EMBL· GenBank· DDBJ | ANE14418.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290673 EMBL· GenBank· DDBJ | ANE14780.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290685 EMBL· GenBank· DDBJ | ANE14936.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290697 EMBL· GenBank· DDBJ | ANE15092.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290713 EMBL· GenBank· DDBJ | ANE15300.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290715 EMBL· GenBank· DDBJ | ANE15326.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290755 EMBL· GenBank· DDBJ | ANE15846.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290757 EMBL· GenBank· DDBJ | ANE15872.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290759 EMBL· GenBank· DDBJ | ANE15898.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290761 EMBL· GenBank· DDBJ | ANE15924.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290763 EMBL· GenBank· DDBJ | ANE15950.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290770 EMBL· GenBank· DDBJ | ANE16041.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU290842 EMBL· GenBank· DDBJ | ANE16974.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU291075 EMBL· GenBank· DDBJ | ANE19999.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU291077 EMBL· GenBank· DDBJ | ANE20025.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU291079 EMBL· GenBank· DDBJ | ANE20051.1 EMBL· GenBank· DDBJ | Genomic DNA |