A0A172R7K2 · A0A172R7K2_CANLF

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological ProcessATP synthesis coupled electron transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 5
  • EC number

Gene names

    • Name
      ND5

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • 135T
    • 136T
    • 137T1
    • 139T
    • 140T
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis

Accessions

  • Primary accession
    A0A172R7K2

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-27Helical
Transmembrane39-58Helical
Transmembrane84-105Helical
Transmembrane117-134Helical
Transmembrane140-160Helical
Transmembrane172-191Helical
Transmembrane245-263Helical
Transmembrane275-294Helical
Transmembrane362-386Helical
Transmembrane406-432Helical
Transmembrane453-472Helical
Transmembrane484-502Helical
Transmembrane586-605Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain68-118NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Domain134-418NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Domain422-601NADH dehydrogenase subunit 5 C-terminal

Sequence similarities

Belongs to the complex I subunit 5 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    606
  • Mass (Da)
    68,360
  • Last updated
    2016-09-07 v1
  • Checksum
    0721751A773BDCFD
MNMFSSCMITALVILTLPIIMSSTKLYKNKLYPYYVKTATSYAFMISMIPTMMFIYSGQETIISNWHWMTIQTMKLSMSFKLDYFSMIFVPVALFVTWSIMEFSMWYMHSDPYINRFFKYLLLFLITMMVLVTANNMFQLFIGWEGVGIMSFLLIGWWYGRTDANTAALQAVLYNRIGDVGFIMTMAWFLLNLNTWDLQQIFITTNDNFNLPLLGLLLAATGKSAQFGLHPWLPSAMEGPTPASALLHSSTMVVAGVFLLIRFHPLMEHNQTIQTLTLCLGAINTLFTAICALTQNDIKKIVAFSTSSQLGLMMVTIGINQPYLAFLHICTHAFFKAMLFMCSGSVIHSLNDEQDIRKMGGLFKVLPFTTTSLIIGSLALTGMPFLTGFYSKDLIIESANTSNTNAWALLITLVATSLTAAYSTRIMFFALLGQPRFSPMILINENNPLLINSIKRLLIGSVFAGYIISHSITPTTIPQMTMPHYLKMTALAVTTLGFILALELNLTTQGLKFNYPSNYFKFSSLLGYYPTIMHRLTPKTSLTISQKSASMLLDSIWLENILPKSISYFQMKSSTLISNQKGLIKLYFLSFMLTMILSLLILNYHG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KU290432
EMBL· GenBank· DDBJ
ANE11651.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290434
EMBL· GenBank· DDBJ
ANE11677.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290436
EMBL· GenBank· DDBJ
ANE11703.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290438
EMBL· GenBank· DDBJ
ANE11729.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290441
EMBL· GenBank· DDBJ
ANE11768.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290443
EMBL· GenBank· DDBJ
ANE11794.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290445
EMBL· GenBank· DDBJ
ANE11820.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290473
EMBL· GenBank· DDBJ
ANE12184.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290481
EMBL· GenBank· DDBJ
ANE12288.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290483
EMBL· GenBank· DDBJ
ANE12314.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290485
EMBL· GenBank· DDBJ
ANE12340.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290487
EMBL· GenBank· DDBJ
ANE12366.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290489
EMBL· GenBank· DDBJ
ANE12392.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290491
EMBL· GenBank· DDBJ
ANE12418.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290493
EMBL· GenBank· DDBJ
ANE12444.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290495
EMBL· GenBank· DDBJ
ANE12470.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290509
EMBL· GenBank· DDBJ
ANE12652.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290513
EMBL· GenBank· DDBJ
ANE12704.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290515
EMBL· GenBank· DDBJ
ANE12730.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290517
EMBL· GenBank· DDBJ
ANE12756.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290583
EMBL· GenBank· DDBJ
ANE13612.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290600
EMBL· GenBank· DDBJ
ANE13833.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290613
EMBL· GenBank· DDBJ
ANE14002.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290631
EMBL· GenBank· DDBJ
ANE14236.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290645
EMBL· GenBank· DDBJ
ANE14418.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290673
EMBL· GenBank· DDBJ
ANE14780.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290685
EMBL· GenBank· DDBJ
ANE14936.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290697
EMBL· GenBank· DDBJ
ANE15092.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290713
EMBL· GenBank· DDBJ
ANE15300.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290715
EMBL· GenBank· DDBJ
ANE15326.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290755
EMBL· GenBank· DDBJ
ANE15846.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290757
EMBL· GenBank· DDBJ
ANE15872.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290759
EMBL· GenBank· DDBJ
ANE15898.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290761
EMBL· GenBank· DDBJ
ANE15924.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290763
EMBL· GenBank· DDBJ
ANE15950.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290770
EMBL· GenBank· DDBJ
ANE16041.1
EMBL· GenBank· DDBJ
Genomic DNA
KU290842
EMBL· GenBank· DDBJ
ANE16974.1
EMBL· GenBank· DDBJ
Genomic DNA
KU291075
EMBL· GenBank· DDBJ
ANE19999.1
EMBL· GenBank· DDBJ
Genomic DNA
KU291077
EMBL· GenBank· DDBJ
ANE20025.1
EMBL· GenBank· DDBJ
Genomic DNA
KU291079
EMBL· GenBank· DDBJ
ANE20051.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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