A0A169MWV6 · A0A169MWV6_9REOV

  • Protein
    Non-structural protein 5
  • Gene
    NSP5
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Plays an essential role in the viral genome replication. Participates, together with NSP2, in the formation of viral factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place. Orchestrates the recruitment of viroplasmic proteins such as capsid proteins to these factories. Participates in the selective exclusion of host proteins from stress granules (SG) and P bodies (PB). Participates also in the sequestration of these remodeled organelles in viral factories.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

121220406080100120140160180200
TypeIDPosition(s)Description
Binding site86Mg2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell cytoplasm
Molecular FunctionATP hydrolysis activity
Molecular Functionmagnesium ion binding
Molecular Functionnucleotide binding
Molecular FunctionRNA binding
Biological Processviral genome replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Non-structural protein 5
  • Short names
    NSP5
  • Alternative names
    • NS26

Gene names

    • Name
      NSP5

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • RVC/Human-wt/JPN/YA-27/2011/G4P[2]
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Duplornaviricota > Resentoviricetes > Reovirales > Sedoreoviridae > Rotavirus > Rotavirus C

Accessions

  • Primary accession
    A0A169MWV6

Proteomes

Subcellular Location

Host cytoplasm
Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

Keywords

PTM/Processing

Post-translational modification

O-glycosylated.

Keywords

Interaction

Subunit

Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2 and NSP6.

Family & Domains

Sequence similarities

Belongs to the rotavirus NSP5 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    212
  • Mass (Da)
    23,771
  • Last updated
    2016-07-06 v1
  • Checksum
    4D1FB7D86C55FA66
MSDFGINLDAICDNVKKSQTESRTGSQLSNRSSRRMDFVDDEELSTYFNSKASVTQSDSCSNDLAMKHSIITEAVVCDESAHVSADAIQEKDETVPQIDHRIMKWMLDSHDGVSLNGGINFTKAKSKLKETENDITEMKSKTNLLVNASVGINSNIGAFNPINQHVKTETVSNIFEDEDIEGCICKSCPYREKYRKLRSKMKNVLIDMINEM

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LC129129
EMBL· GenBank· DDBJ
BAU80905.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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