A0A167IPB8 · A0A167IPB8_METRR
- ProteinDNA repair protein REV1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1146 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
Cofactor
Note: Binds 2 magnesium ions.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 367 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 462 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 463 | Mg2+ 1 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | nucleus | |
Molecular Function | damaged DNA binding | |
Molecular Function | deoxycytidyl transferase activity | |
Molecular Function | DNA-directed DNA polymerase activity | |
Molecular Function | metal ion binding | |
Biological Process | error-free translesion synthesis | |
Biological Process | error-prone translesion synthesis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA repair protein REV1
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Clavicipitaceae > Metarhizium
Accessions
- Primary accessionA0A167IPB8
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 60-148 | BRCT | |||
Region | 159-254 | Disordered | |||
Compositional bias | 166-230 | Polar residues | |||
Compositional bias | 237-251 | Polar residues | |||
Domain | 363-561 | UmuC | |||
Region | 755-826 | Disordered | |||
Compositional bias | 765-780 | Basic and acidic residues | |||
Region | 856-877 | Disordered | |||
Region | 1011-1030 | Disordered | |||
Sequence similarities
Belongs to the DNA polymerase type-Y family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,146
- Mass (Da)126,353
- Last updated2016-07-06 v1
- Checksum738A316271024601
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 166-230 | Polar residues | |||
Compositional bias | 237-251 | Polar residues | |||
Compositional bias | 765-780 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AZHC01000003 EMBL· GenBank· DDBJ | OAA49289.1 EMBL· GenBank· DDBJ | Genomic DNA |