A0A167IPB8 · A0A167IPB8_METRR

Function

function

Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions.

Features

Showing features for binding site.

111461002003004005006007008009001,0001,100
TypeIDPosition(s)Description
Binding site367Mg2+ 1 (UniProtKB | ChEBI)
Binding site462Mg2+ 1 (UniProtKB | ChEBI)
Binding site463Mg2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentnucleus
Molecular Functiondamaged DNA binding
Molecular Functiondeoxycytidyl transferase activity
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionmetal ion binding
Biological Processerror-free translesion synthesis
Biological Processerror-prone translesion synthesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA repair protein REV1
  • EC number

Gene names

    • ORF names
      NOR_01212

Organism names

Accessions

  • Primary accession
    A0A167IPB8

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain60-148BRCT
Region159-254Disordered
Compositional bias166-230Polar residues
Compositional bias237-251Polar residues
Domain363-561UmuC
Region755-826Disordered
Compositional bias765-780Basic and acidic residues
Region856-877Disordered
Region1011-1030Disordered

Sequence similarities

Belongs to the DNA polymerase type-Y family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,146
  • Mass (Da)
    126,353
  • Last updated
    2016-07-06 v1
  • Checksum
    738A316271024601
MGSVLEKNSSLVRKRIEGHKFEDEGGEEYEGSKFGGFGDYFRRKRIKLQNLDADVRAASEKPQIFKGIVAHVTGYTQPPLHVLHREIVQHGGGFLQYLDSKTMATHIIASTLPPKKSIDFSRYRIVKPAWIVDSVAAGKLMPWGEYRVLDEGPRQKVLRFDGEQGMTQASPETRQGYREQTDNSFYTSQFTPTTTLPSQSLSQLAEKTQTPSKSLGSYAVNEQQTPGDRLQALVTPPKSWPTESVESQSALKPTGYDAPDQVMGPPEQPSAIADPESTWPAFTELPAKEVTSEEHNAWLLSDPRLRKSSTANPEFLQQFYSESRLHHLSTWKANLKSAMHRLAAEKGLTQKKFKSKPGTRGYVLHVDFDSFFCSVSLKKHPEYANKPAVVAHSSGPGSEIASCNYPARKFGVKNGMWMKRAVDLCPDLKVLPYDFPAYEEASRLFYESIMSVGGVVQSVSVDEALIDATVIVHSASGSQGVGIDEGNIWREQEKVDEIAAGLRDSIKAKTGCTVSVGIGGNILQAKVALRKAKPAGQFQLKPEDVLDVLGELTVQQLPGVSHSIGGKLEELGIRFVKDIRSVSKERLASSVGPKTSEKLSDYARGIDRTEVGEQPPRKSVSAEVNWGIRFISQQEAEDFVFNLCKELEKRLVNEQVRGTHLTMKIMRRSLDAPMDPAKHLGHGKCDTFNKSATFGVATHNHETIGKEAVSILRSFKFSPGDLRGLGVQMTKLEPIKAQQACPMESSQRTLSFGQFAGSSSAKKKKAGAETIDDVESPQKPRRSPGHGITDADPIADDPLTPRKPKVHPAMALSKAGQEDGKANTPLNVSGTQFILPSNPDPAVIAELPNDIRSRLMGQQRSRQSPSPAVSRSESPAAATELLPSQIDADVFNALPDDMKAEVLASYGRRPVRLQSPRKDHHPLIQQRKQTTPTKRGGGIRSMFGKVQRQRDAQTGIVQTSFRPLETGVESPVIEEIEELDAEFLAELPEDVRKEVVADHRRRRMALRSGLDAPPRRHFAPDTESVFPGGGQKKITFPAPPRKVAFANSGVSSTREIKDMLDAWHTETRHEGPHSGDVEVFEKYLAKVVRGERDLEKVAVLIRWLDVIVEQDGSSGKGQDSWREAVRQVKSTVQTAMKERGLGPLDI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias166-230Polar residues
Compositional bias237-251Polar residues
Compositional bias765-780Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AZHC01000003
EMBL· GenBank· DDBJ
OAA49289.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help