A0A166HFK9 · A0A166HFK9_SECCO
- ProteinLexA repressor
- GenelexA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids209 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
Catalytic activity
Features
Showing features for dna binding, site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
DNA binding | 29-49 | H-T-H motif | |||
Site | 94-95 | Cleavage; by autolysis | |||
Active site | 130 | For autocatalytic cleavage activity | |||
Active site | 168 | For autocatalytic cleavage activity | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | DNA binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | DNA repair | |
Biological Process | DNA replication | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | proteolysis | |
Biological Process | SOS response |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLexA repressor
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillati > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Secundilactobacillus
Accessions
- Primary accessionA0A166HFK9
Proteomes
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 8-66 | LexA repressor DNA-binding | |||
Domain | 87-201 | Peptidase S24/S26A/S26B/S26C | |||
Sequence similarities
Belongs to the peptidase S24 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length209
- Mass (Da)23,102
- Last updated2016-07-06 v1
- MD5 ChecksumE756B6A46CA9CA5A632BA151889532EA
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JYDC01000022 EMBL· GenBank· DDBJ | KZL42609.1 EMBL· GenBank· DDBJ | Genomic DNA |