A0A166HFK9 · A0A166HFK9_SECCO

Function

function

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Hydrolysis of Ala-|-Gly bond in repressor LexA.
    EC:3.4.21.88 (UniProtKB | ENZYME | Rhea)

Features

Showing features for dna binding, site, active site.

120920406080100120140160180200
Type
IDPosition(s)Description
DNA binding29-49H-T-H motif
Site94-95Cleavage; by autolysis
Active site130For autocatalytic cleavage activity
Active site168For autocatalytic cleavage activity

GO annotations

AspectTerm
Molecular FunctionDNA binding
Molecular Functionserine-type endopeptidase activity
Biological ProcessDNA repair
Biological ProcessDNA replication
Biological Processnegative regulation of DNA-templated transcription
Biological Processproteolysis
Biological ProcessSOS response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    LexA repressor
  • EC number

Gene names

    • Name
      lexA
    • ORF names
      TY91_03910

Organism names

Accessions

  • Primary accession
    A0A166HFK9

Proteomes

PTM/Processing

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-66LexA repressor DNA-binding
Domain87-201Peptidase S24/S26A/S26B/S26C

Sequence similarities

Belongs to the peptidase S24 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    209
  • Mass (Da)
    23,102
  • Last updated
    2016-07-06 v1
  • MD5 Checksum
    E756B6A46CA9CA5A632BA151889532EA
MTKSSETKQLSILQYIYDQTQEHGYPPTVREIGEAVGLSSTSTVHGHIARLTKKGYLIKDPTKPRALEVTDNGIDALGIQLTPTKIPVLGTVTAGQPILAVQEAVDYFPIPDELEDEASDLFMLTIRGESMINDAILNGDKVIVKKQHSADNGDIVIAMTEDNEATCKRFYKEDNYYRLQPANDTMAPIILDTVTILGKVIGVYRDHIQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JYDC01000022
EMBL· GenBank· DDBJ
KZL42609.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice.
Help