A0A163PEE5 · A0A163PEE5_STAAU

  • Protein
    D-alanine--D-alanyl carrier protein ligase
  • Gene
    dltA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Pathway

Cell wall biogenesis; lipoteichoic acid biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site144-145ATP (UniProtKB | ChEBI)
Binding site189D-alanine (UniProtKB | ChEBI)
Binding site284-289ATP (UniProtKB | ChEBI)
Binding site293D-alanine (UniProtKB | ChEBI)
Binding site365ATP (UniProtKB | ChEBI)
Binding site473ATP (UniProtKB | ChEBI)
Binding site473D-alanine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionD-alanine [D-alanyl carrier protein] ligase activity
Biological Processlipoteichoic acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    D-alanine--D-alanyl carrier protein ligase
  • EC number
  • Short names
    DCL
  • Alternative names
    • D-alanine--poly(phosphoribitol) ligase subunit 1
    • D-alanine-activating enzyme
      (DAE
      )

Gene names

    • Name
      dltA
    • Synonyms
      dltA_1
    • ORF names
      GZ164_12630
      , NCTC7878_00614
      , NCTC7972_01039
      , SAMEA1531725_00822

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • EOE173
    • NCTC7878
    • NCTC7972
    • 29-017
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus

Accessions

  • Primary accession
    A0A163PEE5

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-342AMP-dependent synthetase/ligase
Domain395-473AMP-binding enzyme C-terminal

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    485
  • Mass (Da)
    54,585
  • Last updated
    2016-07-06 v1
  • Checksum
    8F44ECA752ECF633
MTDIINKLQAFADANPQSIAVRHTTDELTYQQLMDESSKLAHRLQGSKKPMILFGHMSPYMIVGMIGAIKAGCGYVPVDTSIPEDRIKMIINKVQPEFVFNTTDESFESLAGEVFTIEDIKTSQDPVIFDSQIKDNDTVYTIFTSGSTGEPKGVQIEYASLVQFTEWMLELNKSGNEQQWLNQAPFSFDLSVMAIYPCLASGGTLNLVDKNMINKPKLLNEMLTATPINIWVSTPSFMEMCLLLPTLNEEQYGSLNEFFFCGEILPHRAAKALVSRFPSATIYNTYGPTEATVAVTSIQITQEILDQYPTLPVGVERPGARLSTTDEGELVIEGQSVSLGYLKNDQKTAEVFNFDDGIRTYHTGDKAKFENGQWFIQGRIDFQIKLNGYRMELEEIETQLRQSEFVKEAIVVPVYKNDKVIHLIGAIVPTTEVTDNAEMTKNIKNDLKSRLPEYMIPRKFEWMEQLPLTSNGKIDRKKIAEVING

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAFMT010000029
EMBL· GenBank· DDBJ
NDR17196.1
EMBL· GenBank· DDBJ
Genomic DNA
UAUX01000004
EMBL· GenBank· DDBJ
SPZ97222.1
EMBL· GenBank· DDBJ
Genomic DNA
UELG01000004
EMBL· GenBank· DDBJ
SRZ65215.1
EMBL· GenBank· DDBJ
Genomic DNA
UHAI01000002
EMBL· GenBank· DDBJ
SUK17162.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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