A0A162PR45 · A0A162PR45_PHYB8
- ProteinUncharacterized protein
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2258 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- 2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H+ + L-glutamate + phosphate
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 352 | Nucleophile | ||||
Sequence: C | ||||||
Active site | 436 | |||||
Sequence: H | ||||||
Active site | 438 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | amino acid binding | |
Molecular Function | aspartate carbamoyltransferase activity | |
Molecular Function | ATP binding | |
Molecular Function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity | |
Molecular Function | dihydroorotase activity | |
Molecular Function | metal ion binding | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process | |
Biological Process | citrulline biosynthetic process | |
Biological Process | glutamine metabolic process | |
Biological Process | UTP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Mucoromycotina > Mucoromycetes > Mucorales > Phycomycetaceae > Phycomyces
Accessions
- Primary accessionA0A162PR45
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-51 | Disordered | ||||
Sequence: MASGFPIPSVADAGTAPSTGTNSRIPVPAANSTPLPFSLRSHSGPQPAATA | ||||||
Compositional bias | 14-48 | Polar residues | ||||
Sequence: GTAPSTGTNSRIPVPAANSTPLPFSLRSHSGPQPA | ||||||
Domain | 612-804 | ATP-grasp | ||||
Sequence: AQALFEINEKCAPSASAISIDEALKAAEDIGYPVICRAAYALGGLGSGFANNENELIALCNKAFATSPQVLVEKSMKGWKEIEYEVVRDCQDNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDDDYNMLRTTAVNVIRHLGVVGECNIQYALNPFSKEYCIIEVNARLSRSSALASKATGYPLAFVAAKLGL | ||||||
Domain | 1151-1342 | ATP-grasp | ||||
Sequence: SRMCDQIGVDQPLWKELTSYDEADDFCNKVGYPVLVRPSYVLSGAAMNVVFSKDDLASYLNEAAAVSRDHPVVISKYIEEAKEIEMDAVALDGKMIMHVISEHVENAGVHSGDATLVLPPQDLDPETVRKIEIATAKIGRALNVTGPYNIQFIAKDNEIKVIECNVRASRSFPFVSKVLGVDLIEMATNAML | ||||||
Domain | 1408-1562 | MGS-like | ||||
Sequence: FTIPKKNILLSIGSYKEKMEMLPSVRKLHNLGYILFATAGTADFIQEHNIPVKYLEVLDGGSDVLKAEYSLQQHLAKNLIDLYINLPSRNRYRRPASYMSKGYRSRRMAVDYDIPLLTNVKCAKVFVEALARNPTGDYDILGIDYKTGHTSATLP | ||||||
Region | 1898-1919 | Disordered | ||||
Sequence: KPMSSDTASDENIRRPNPEKHA | ||||||
Compositional bias | 1900-1919 | Basic and acidic residues | ||||
Sequence: MSSDTASDENIRRPNPEKHA |
Sequence similarities
In the 2nd section; belongs to the CarB family.
In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.
In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
In the N-terminal section; belongs to the CarA family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,258
- Mass (Da)248,338
- Last updated2016-07-06 v1
- ChecksumE006372E002B7496
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 14-48 | Polar residues | ||||
Sequence: GTAPSTGTNSRIPVPAANSTPLPFSLRSHSGPQPA | ||||||
Compositional bias | 1900-1919 | Basic and acidic residues | ||||
Sequence: MSSDTASDENIRRPNPEKHA |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KV440984 EMBL· GenBank· DDBJ | OAD72146.1 EMBL· GenBank· DDBJ | Genomic DNA |