A0A162LX07 · A0A162LX07_METRR

Function

function

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site82ATP (UniProtKB | ChEBI)
Binding site89-91ATP (UniProtKB | ChEBI)
Binding site150ATP (UniProtKB | ChEBI)
Binding site242Mg2+ (UniProtKB | ChEBI)
Binding site256Mg2+ (UniProtKB | ChEBI)
Binding site307substrate; ligand shared with subunit alpha
Binding site364-366substrate; ligand shared with subunit alpha

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentsuccinate-CoA ligase complex
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionsuccinate-CoA ligase (ADP-forming) activity
Biological Processsuccinyl-CoA metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
  • EC number
  • Alternative names
    • Succinyl-CoA synthetase beta chain
      (SCS-beta
      )

Gene names

    • ORF names
      NOR_02973

Organism names

Accessions

  • Primary accession
    A0A162LX07

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterodimer of an alpha and a beta subunit.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain45-91ATP-grasp

Sequence similarities

Belongs to the succinate/malate CoA ligase beta subunit family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    447
  • Mass (Da)
    48,381
  • Last updated
    2016-07-06 v1
  • Checksum
    EFADF1825466592B
MLNLGRSRALASAFNASKLQVAPAVRIPGIAHQRRALSIHEYLSADLLRQYGVGVPKGSVAKTAEEAKAVAKEIGTEDMVIKAQVLAGGRGKGTFDNGLKGGVRVIYSPHEAEMFAHQMIGHKLITKQTGAGGRLCNAVYICERKFARREFYLAILMDRTSQSPVIVSSSQGGMDIETVAKESPDAIVTTYIDINTGVTDDIARGIATKLGFSEQCIEDAKDTIQKLYKIFVERDSTQIEINPLSETNDHQVLCMDAKFGFDDNADFRQKEVFEWRDTTQEDPDEVRAAKSGLNFIKLDGDIGCLVNGAGLAMATMDIIKLNGGQPANFLDVGGGATPAAIQEAFELITSDPKVTAIFVNIFGGIVRCDHIATGLIKTVENLNLKIPIIARLQGTNVEQAHKIINESGMKIFSIDDLQNAAEKSVQLSKVVKLARDIDVGVEFSLGI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AZHC01000007
EMBL· GenBank· DDBJ
OAA46220.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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