A0A162I360 · A0A162I360_METRR

Function

function

Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular Componentmitochondrion
Cellular Componentnucleus
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Function5'-flap endonuclease activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Molecular Functionsingle-stranded DNA helicase activity
Biological ProcessDNA repair
Biological ProcessDNA replication, Okazaki fragment processing
Biological Processreplication fork reversal

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA replication ATP-dependent helicase/nuclease
  • EC number

Gene names

    • ORF names
      NOR_00308

Organism names

Accessions

  • Primary accession
    A0A162I360

Proteomes

Subcellular Location

Mitochondrion
Nucleus
Chromosome

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias1-27Polar residues
Region1-76Disordered
Region125-156Disordered
Region228-262Disordered
Compositional bias245-262Polar residues
Region275-329Disordered
Compositional bias290-305Basic and acidic residues
Compositional bias306-322Polar residues
Domain451-653DNA replication factor Dna2 N-terminal
Domain661-763DUF83
Domain825-916DNA2 rift barrel
Domain1016-1104DNA2/NAM7 helicase helicase
Domain1118-1184DNA2/NAM7 helicase helicase
Domain1193-1421DNA2/NAM7 helicase-like C-terminal
Region1460-1502Disordered

Sequence similarities

Belongs to the DNA2/NAM7 helicase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,529
  • Mass (Da)
    170,885
  • Last updated
    2016-07-06 v1
  • Checksum
    8661ADDFFA940193
MPLQKSYSEHNRSSWQRSHSHPTNLQAQRPRPLPPVSDVTKKKLSRFQYEPQASVLGGAGDTSAKPEDATASGTGVVANAATPVTRLNWRDLLEPNAAPVEDEVEISPNDKLLWNNQQDTLYAAVLSPTMPRKGKKRARSSSPSSSPANEKGTWPTVNVDKLKTALRSPHADPTLELWDRYSLKDSEDITTPNGAGFTALAQLMVSSSPKPSKEVSVRRGDANLRRAISCGLNWPKRRKTERSKSGSQSSSQQREMEAASKSSLVTALLDTVTSSVNGPDPIWTREQLLRSPSPKKRRLSPKRSETPCRAKTSLLSSSPSSDYGDDDLDDDTFMELEASMQITGTTNTSLPDSIDQGQLSGRQLHSRRNNFLNSAEEFDDVMLPQQPALGVSTPKNQSRCNLIANIEESMCDEFEDEFDGDIDFDAVELAATQSIQQLEAPSGSILIIQADNSKITKTVHLRGAWFDTPAHTKSYVHIIGSFSARGQCIIDDKQNLLILHPDQLISSTVVADSFGCLRRAVLQDRVKATSESSPPLVYGTMLHEIFQEALMENQWDLPFLSRIVDKITEKHVEDLYTIKIGLPSAKEHLLSKMTELSCWAKTFVTSKPQADAVVEDRNGKKANMAITKLLDVEEHVWSPMYGLKGNIDATVEVAMSDGKQTRTLTVPFEVKTGKHANSNHMAQTALYTLLLSDRYDVDITYGILYYMETSKIMRIPAIQHELRHMILQRNQLACYIRERSVQLPPMLKSKLMCGQCYAKTSCFTYHRLADDGDGESSGMHEKFDGLVKHLTSTHQEFFVRWENLLTMEEKESQKTKRELWTMTSAEREKKSRCFSDVIIEEGSATVDTDNPRINRFHYTFIKRDQQPGFSFMESELTSGEPVVVSDEEGHFALAIGYVTSVRKERISVAVDRRLHNSRIRQPGFDEIDNQVFASIMDVAQGKPSDREQRKVREPPVRYRLDKDEFSNGMATVRNNLVQMMANEVPAASQMRRLIVDLAPPRFKTAPTQYTVTDGENLNVDQKRAIEKVMSTQDYSLVLGMPGTGKTTTIAHIIRALVSQGKTVLLTSHTHTAVDNILLKLRADKIPILRLGAPAKIHPDVQDFAHLAGQTKKTFDEIKEAWHGTPVVATTCLGINHPVFLERLFDYCIVDEASQITLPICAGPIRLASSFVLVGDHNQLPPVVRNEDARQGGLDASLFKLLSDAHPEAVVNLEHQYRMCEDIMTLSNTLIYDGKLRCGTESLRKKKLHVPNMSALSRVHFNASLLARPGTPRSFCTGPSPSRCWLYDLLESEARVRFVNTDTIRPLVREEAQGKRIVNSAEVRLVTQLVESFLAVGIPASEVGVMTHYRAQLFLLKEQLKGYAGVEMHTTDRFQGRDKEVVVLSLVRSNEANNIGDLLKDWRRINVAFTRAKTKLLVVGSMNTLKHSGKENMLSKFISLMEERDWIYDLPADALESHHFEGLSTPTVGRTPSLKSPKKAPKKGVPSFQGKENRRPSPKKARIGERALLRGKLVTKDILNEMTNGAYMGV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-27Polar residues
Compositional bias245-262Polar residues
Compositional bias290-305Basic and acidic residues
Compositional bias306-322Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AZHC01000001
EMBL· GenBank· DDBJ
OAA51715.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp