A0A162I067 · A0A162I067_METRR

Function

function

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site20phosphate (UniProtKB | ChEBI)
Binding site62-63phosphate (UniProtKB | ChEBI)
Binding site95-96phosphate (UniProtKB | ChEBI)
Site179Important for substrate specificity
Binding site197substrate
Binding site198phosphate (UniProtKB | ChEBI)
Binding site221-223substrate
Site233Important for substrate specificity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionS-methyl-5-thioadenosine phosphorylase activity
Biological ProcessL-methionine salvage from methylthioadenosine
Biological Processpurine ribonucleoside salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-methyl-5'-thioadenosine phosphorylase
  • EC number
  • Alternative names
    • 5'-methylthioadenosine phosphorylase
      (MTA phosphorylase
      ; MTAP
      ; MTAPase
      )

Gene names

    • ORF names
      NOR_01025

Organism names

Accessions

  • Primary accession
    A0A162I067

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotrimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain14-255Nucleoside phosphorylase

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    307
  • Mass (Da)
    33,788
  • Last updated
    2016-07-06 v1
  • Checksum
    A4767B4659CF75A6
MSNLPTTFDKPVHIAVIGGTGLGHLEGYEPVASINPITPWGSPASPIKILSHNGTYIAFLARHGLHHQYAPHEVPNRANIAALRHLGVRCVIAFSAVGSLQEDIKPMDFVVPDQVIDRTKGIRPFTFFERGVVGHVGFADPFDSGLAAVVKRCAESMEGDGVVLHEKGTVIVMEGPQFSTRAESHMYRSWGGSVINMSTLPEAKLAREAELSYQVIAMATDYDCWHSFEDVNVDMVIKYMHQNGKNAKRLVGAVLDQLSNLEHSDLVMAKKWEGYSQGGLKFMTKPEGRDPEAMKKVEYLFPGVWSS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AZHC01000002
EMBL· GenBank· DDBJ
OAA50575.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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