A0A161TQL4 · A0A161TQL4_XYLHT

Function

function

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular ComponentSet1C/COMPASS complex
Molecular Functionhistone H3K4 trimethyltransferase activity
Molecular Functionnucleic acid binding
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone-lysine N-methyltransferase, H3 lysine-4 specific
  • EC number

Gene names

    • ORF names
      L228DRAFT_266972

Organism names

Accessions

  • Primary accession
    A0A161TQL4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Component of the COMPASS (Set1C) complex.
Component of the Set1C/COMPASS complex.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-31Disordered
Compositional bias122-150Polar residues
Region122-162Disordered
Region378-428Disordered
Compositional bias394-408Pro residues
Region523-550Disordered
Compositional bias533-550Basic and acidic residues
Compositional bias616-637Basic and acidic residues
Region616-659Disordered
Region677-783Disordered
Compositional bias701-731Basic and acidic residues
Compositional bias746-775Basic and acidic residues
Region848-955Disordered
Compositional bias852-866Basic and acidic residues
Compositional bias895-918Basic and acidic residues
Compositional bias919-941Acidic residues
Domain1139-1256SET
Domain1265-1281Post-SET

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,281
  • Mass (Da)
    142,778
  • Last updated
    2016-07-06 v1
  • Checksum
    BA7EA1BF5C0FF6C1
MSFADFFPAAPKAAKRAAEERQRARGKPTDILSATSVSAGVIVRPSGSEDSQISRPGGVTSGSIIEQAVTGQEDSESVPGDLLNGVGSASSHASTVSSVFSANNQLSIISNAGAISNLHNLTPLTNTESSPPGKAPSSPQFKSTYGHTPTDGSPGFVEPLPDSDAMVANAMTPAHTPLESRLSARPAGVKGSIATYDPELDPKLNSKQKRKLKAVYREFGEEDDDLPPKDPRLAIPHYTKGAANKPKCKLRTAPYILKAFPFDSATSVGPGPPTQVVVTGFNPLTPVSHINALFSSFGEIAETSNKTDPISGSLLGVCSIRYKDRIVRGAAPQLAIDAARRAEKGGTGQRIGTYTVRVERDREGRRCRRAVEAVLHRLRGEEKKPEEKETPPQTVPNSAPPPTAPKGPSVKVAPKIPEGPKNTSRPGFPSLVEESPILNQLKREPYIFIAHCYVPVLSTTVSHLKKRLKAFDWKEVRLDKTGYYVIFDNSRRGEDEALRCYKACHMTPLFTYIMNMECQQYGNPSYERSPSPGQVEAEKRDKAERERRRVEYEQEIEIQKKQRASDLDPVREAADIVRRELIEKLLSDIKSRIAGPALFNYLDPDRHVDKRRRLGISDPYDTRRPTIHIERTDESPLAGTPDSRADPMAAGQRRPLGSSTLNITALPRIRKGAGTKQGIVGFADERRKRPVPRKADIRPLHHRLHQFYDEEDSEDEQRTPMTRDTEEQESRPLSRMSTTSAESEDENAKVPVKDRTEEDLESRWGGEDEGEDGQATTFIHSDAYRDETVDASIEELAREANMLPLSSKKRKRLLKELEARKKQREDDKLFGIEREDIETFEAAPINIEIEVPGEEQEVKAEAETPVEDLGELPDATEATAKTKPKKKGAKPKKKSKKQLFEERELKKAQERALLEDIQEEQPAEEIEEEPQPEEEIEPEAEVEPPRAEVEWGVSSDVPRRTVEDDESIILDLDGWQHLIKDNEDLHFLQDVLKDEPEADLGHAAAWAWKQKEIKALNRGGERGPVRSKTMIEGYYVPNASGSARTEGTKKILESEKSKYLPHRIRVQKAREEREAQAKNETQSVVDAAKLAAAKSISGSSSRSNRANNRRLVADINAQKQVISGDADVLRFNQLKKRKKPVKFARSAIHNWGLYAMENISANDMIIEYVGEKVRQQVADMRERRYLKSGIGSSYLFRIDETTVIDATKRGGIARFINHSCTPNCTAKIIKVEGSKRIVIYALRDIAQNEELTYDYKFEREFDSDDRIPCLCGSSGCKGFLN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias122-150Polar residues
Compositional bias394-408Pro residues
Compositional bias533-550Basic and acidic residues
Compositional bias616-637Basic and acidic residues
Compositional bias701-731Basic and acidic residues
Compositional bias746-775Basic and acidic residues
Compositional bias852-866Basic and acidic residues
Compositional bias895-918Basic and acidic residues
Compositional bias919-941Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KV407456
EMBL· GenBank· DDBJ
KZF24656.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp