A0A161TP81 · A0A161TP81_XYLHT
- ProteinCeramide very long chain fatty acid hydroxylase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids398 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 Zn2+ ions per subunit that likely form a catalytic dimetal center.
Pathway
Lipid metabolism.
Sphingolipid metabolism.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | fatty acid 2-hydroxylase activity | |
Molecular Function | heme binding | |
Molecular Function | iron ion binding | |
Biological Process | fatty acid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCeramide very long chain fatty acid hydroxylase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Xylonomycetes > Xylonales > Xylonaceae > Xylona
Accessions
- Primary accessionA0A161TP81
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 210-232 | Helical | ||||
Sequence: WWVVPLVWVPPVIYGTLLSAANL | ||||||
Transmembrane | 238-256 | Helical | ||||
Sequence: AALYWTSGLCLWTLVEYLM | ||||||
Transmembrane | 318-337 | Helical | ||||
Sequence: YNWYAATAVYCGGIFGYICY |
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-85 | Cytochrome b5 heme-binding | ||||
Sequence: LPTILRQDVESHNTAQSCYVTCGTKVYDVTSFLNDHPGGGDLILEFAGKDVTDIMADEISHTHSEAAYEILDDCLVGFMP | ||||||
Region | 91-114 | Disordered | ||||
Sequence: DSAAKSTRPDEIVPLPPSKAGMQE |
Sequence similarities
Belongs to the sterol desaturase family. SCS7 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length398
- Mass (Da)45,143
- Last updated2016-07-06 v1
- ChecksumB3FACF14D514A745
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KV407456 EMBL· GenBank· DDBJ | KZF23946.1 EMBL· GenBank· DDBJ | Genomic DNA |