A0A161TP81 · A0A161TP81_XYLHT

Function

function

Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.

Cofactor

Protein has several cofactor binding sites:
Fe cation (UniProtKB | Rhea| CHEBI:24875 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit that likely form a catalytic dimetal center.

Pathway

Lipid metabolism.
Sphingolipid metabolism.

Features

Showing features for binding site.

139850100150200250300350
TypeIDPosition(s)Description
Binding site41Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue
Binding site68Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionfatty acid 2-hydroxylase activity
Molecular Functionheme binding
Molecular Functioniron ion binding
Biological Processfatty acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ceramide very long chain fatty acid hydroxylase
  • EC number

Gene names

    • ORF names
      L228DRAFT_244809

Organism names

Accessions

  • Primary accession
    A0A161TP81

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane210-232Helical
Transmembrane238-256Helical
Transmembrane318-337Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain6-85Cytochrome b5 heme-binding
Region91-114Disordered

Sequence similarities

Belongs to the sterol desaturase family. SCS7 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    398
  • Mass (Da)
    45,143
  • Last updated
    2016-07-06 v1
  • Checksum
    B3FACF14D514A745
MPARTLPTILRQDVESHNTAQSCYVTCGTKVYDVTSFLNDHPGGGDLILEFAGKDVTDIMADEISHTHSEAAYEILDDCLVGFMPTEPVLDSAAKSTRPDEIVPLPPSKAGMQELKSNGAADGLSTAREPLYAATGMSTAEDLSKDTDYENDFRQHKFLDLNQPLMKQVFFGGFSKAFYLEQVHRPRHYKGGASAPLFGNFLEPLSKTPWWVVPLVWVPPVIYGTLLSAANLSSPLEAALYWTSGLCLWTLVEYLMHRFLFHLDDHLPDNRFFITLHFTLHGIHHYLPMDRYRLVMPPTLFLALATPFWKLAHAVFFYNWYAATAVYCGGIFGYICYDLTHYFLHHRTLPAYYRELKKYHLAHHFADYQLGFGVTSKFWDRIFGTELSVGGTKTMKSQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KV407456
EMBL· GenBank· DDBJ
KZF23946.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp