A0A159BF96 · A0A159BF96_MICSO
- ProteinCellular tumor antigen p53
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids104 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | mitochondrial matrix | |
Cellular Component | PML body | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | apoptotic process | |
Biological Process | rhythmic process |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCellular tumor antigen p53
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Cricetidae > Arvicolinae > Microtus
Accessions
- Primary accessionA0A159BF96
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Binds DNA as a homotetramer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-104 | p53 DNA-binding | ||||
Sequence: PVQLWVSSTPPPGTRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEGNLRAEYLDDRQTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGG |
Sequence similarities
Belongs to the p53 family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length104
- Mass (Da)11,752
- Last updated2016-07-06 v1
- ChecksumC477D6B31AD68F2E
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: P | ||||||
Non-terminal residue | 104 | |||||
Sequence: G |