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A0A159BF92 · A0A159BF92_9RODE

Function

function

Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site.

1104102030405060708090100
TypeIDPosition(s)Description
Binding site35Zn2+ (UniProtKB | ChEBI)
Binding site38Zn2+ (UniProtKB | ChEBI)
Binding site97Zn2+ (UniProtKB | ChEBI)
Binding site101Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentmitochondrial matrix
Cellular ComponentPML body
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processapoptotic process
Biological Processrhythmic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cellular tumor antigen p53

Organism names

  • Taxonomic identifier
  • Strain
    • P-26-704
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Cricetidae > Arvicolinae > Microtus

Accessions

  • Primary accession
    A0A159BF92

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Binds DNA as a homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-104p53 DNA-binding

Sequence similarities

Belongs to the p53 family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    104
  • Mass (Da)
    11,736
  • Last updated
    2016-07-06 v1
  • MD5 Checksum
    3E54BD7DE2187051DFAE76366ADEDBD2
PVQLWVSATPPPGTRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEGNLRAEYLDDRQTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGG

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue104

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KP057416
EMBL· GenBank· DDBJ
ALA55703.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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