A0A159BF92 · A0A159BF92_9RODE
- ProteinCellular tumor antigen p53
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids104 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 35 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 38 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 97 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 101 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | mitochondrial matrix | |
Cellular Component | PML body | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | apoptotic process | |
Biological Process | rhythmic process |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCellular tumor antigen p53
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Cricetidae > Arvicolinae > Microtus
Accessions
- Primary accessionA0A159BF92
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Binds DNA as a homotetramer.
Structure
Sequence
- Sequence statusFragment
- Length104
- Mass (Da)11,736
- Last updated2016-07-06 v1
- MD5 Checksum3E54BD7DE2187051DFAE76366ADEDBD2
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 104 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KP057416 EMBL· GenBank· DDBJ | ALA55703.1 EMBL· GenBank· DDBJ | Genomic DNA |