A0A158SIU0 · A0A158SIU0_HUMAN
- ProteinMethylcytosine dioxygenase TET
- GeneTET2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2002 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Catalytic activity
- 2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H+ + succinate
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Fe2+ ion per subunit.
Note: The zinc ions have a structural role.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | nucleus | |
Molecular Function | 5-methylcytosine dioxygenase activity | |
Molecular Function | zinc ion binding | |
Biological Process | 5-methylcytosine catabolic process | |
Biological Process | chromosomal 5-methylcytosine DNA demethylation pathway | |
Biological Process | regulation of gene expression | |
Biological Process | response to organic cyclic compound |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMethylcytosine dioxygenase TET
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A158SIU0
Organism-specific databases
Subcellular Location
Disease & Variants
Organism-specific databases
Expression
Gene expression databases
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-22 | Disordered | ||||
Sequence: MEQDRTNHVEGNRLSPFLIPSP | ||||||
Region | 113-154 | Disordered | ||||
Sequence: KQDQKANGERRNFGVSQERNPGESSQPNVSDLSDKKESVSSV | ||||||
Compositional bias | 121-154 | Polar residues | ||||
Sequence: ERRNFGVSQERNPGESSQPNVSDLSDKKESVSSV | ||||||
Compositional bias | 266-286 | Polar residues | ||||
Sequence: HPSHTSGQINSAQTSNSELPP | ||||||
Region | 266-287 | Disordered | ||||
Sequence: HPSHTSGQINSAQTSNSELPPK | ||||||
Region | 349-368 | Disordered | ||||
Sequence: GEEFCSGSSSNLQAPGGSSE | ||||||
Region | 390-488 | Disordered | ||||
Sequence: DSFSATTTPPPPSQLLLSPPPPLPQVPQLPSEGKSTLNGGVLEEHHHYPNQSNTTLLREVKIEGKPEAPPSQSPNPSTHVCSPSPMLSERPQNNCVNRN | ||||||
Compositional bias | 401-417 | Pro residues | ||||
Sequence: PSQLLLSPPPPLPQVPQ | ||||||
Compositional bias | 463-488 | Polar residues | ||||
Sequence: PNPSTHVCSPSPMLSERPQNNCVNRN | ||||||
Region | 703-748 | Disordered | ||||
Sequence: LNQQASETEPFSNSHLLQHKPHKQAAQTQPSQSSHLPQNQQQQQKL | ||||||
Region | 930-949 | Disordered | ||||
Sequence: VPDQGGSHTQTPPQKDTQKH | ||||||
Compositional bias | 932-946 | Polar residues | ||||
Sequence: DQGGSHTQTPPQKDT | ||||||
Region | 1075-1095 | Disordered | ||||
Sequence: DSHTPALEQQTTSSEKTPTKR | ||||||
Domain | 1290-1905 | Methylcytosine dioxygenase TET1-3 oxygenase | ||||
Sequence: SWSMYYNGCKFARSKIPRKFKLLGDDPKEEEKLESHLQNLSTLMAPTYKKLAPDAYNNQIEYEHRAPECRLGLKEGRPFSGVTACLDFCAHAHRDLHNMQNGSTLVCTLTREDNREFGGKPEDEQLHVLPLYKVSDVDEFGSVEAQEEKKRSGAIQVLSSFRRKVRMLAEPVKTCRQRKLEAKKAAAEKLSSLENSSNKNEKEKSAPSRTKQTENASQAKQLAELLRLSGPVMQQSQQPQPLQKQPPQPQQQQRPQQQQPHHPQTESVNSYSASGSTNPYMRRPNPVSPYPNSSHTSDIYGSTSPMNFYSTSSQAAGSYLNSSNPMNPYPGLLNQNTQYPSYQCNGNLSVDNCSPYLGSYSPQSQPMDLYRYPSQDPLSKLSLPPIHTLYQPRFGNSQSFTSKYLGYGNQNMQGDGFSSCTIRPNVHHVGKLPPYPTHEMDGHFMGATSRLPPNLSNPNMDYKNGEHHSPSHIIHNYSAAPGMFNSSLHALHLQNKENDMLSHTANGLSKMLPALNHDRTACVQGGLHKLSDANGQEKQPLALVQGVASGAEDNDEVWSDSEQSFLDPDIGGVAVAPTHGSILIECAKRELHATTPLKNPNRNHPTRISLVFYQHK | ||||||
Region | 1475-1507 | Disordered | ||||
Sequence: AAEKLSSLENSSNKNEKEKSAPSRTKQTENASQ | ||||||
Compositional bias | 1484-1498 | Basic and acidic residues | ||||
Sequence: NSSNKNEKEKSAPSR | ||||||
Region | 1521-1587 | Disordered | ||||
Sequence: VMQQSQQPQPLQKQPPQPQQQQRPQQQQPHHPQTESVNSYSASGSTNPYMRRPNPVSPYPNSSHTSD | ||||||
Compositional bias | 1538-1587 | Polar residues | ||||
Sequence: PQQQQRPQQQQPHHPQTESVNSYSASGSTNPYMRRPNPVSPYPNSSHTSD | ||||||
Compositional bias | 1932-1959 | Basic and acidic residues | ||||
Sequence: CEKYGPDYVPQKSHGKKVKREPAEPHET | ||||||
Region | 1932-1961 | Disordered | ||||
Sequence: CEKYGPDYVPQKSHGKKVKREPAEPHETSE |
Sequence similarities
Belongs to the TET family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,002
- Mass (Da)223,811
- Last updated2016-06-08 v1
- Checksum6D740305EE2A8D46
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 121-154 | Polar residues | ||||
Sequence: ERRNFGVSQERNPGESSQPNVSDLSDKKESVSSV | ||||||
Compositional bias | 266-286 | Polar residues | ||||
Sequence: HPSHTSGQINSAQTSNSELPP | ||||||
Compositional bias | 401-417 | Pro residues | ||||
Sequence: PSQLLLSPPPPLPQVPQ | ||||||
Compositional bias | 463-488 | Polar residues | ||||
Sequence: PNPSTHVCSPSPMLSERPQNNCVNRN | ||||||
Compositional bias | 932-946 | Polar residues | ||||
Sequence: DQGGSHTQTPPQKDT | ||||||
Compositional bias | 1484-1498 | Basic and acidic residues | ||||
Sequence: NSSNKNEKEKSAPSR | ||||||
Compositional bias | 1538-1587 | Polar residues | ||||
Sequence: PQQQQRPQQQQPHHPQTESVNSYSASGSTNPYMRRPNPVSPYPNSSHTSD | ||||||
Compositional bias | 1932-1959 | Basic and acidic residues | ||||
Sequence: CEKYGPDYVPQKSHGKKVKREPAEPHET |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FM992369 EMBL· GenBank· DDBJ | CAX30492.1 EMBL· GenBank· DDBJ | mRNA |