A0A158RZH7 · A0A158RZH7_9SPHN
- ProteinTryptophan 2,3-dioxygenase
- GenekynA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids259 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
Catalytic activity
- L-tryptophan + O2 = N-formyl-L-kynurenine
Cofactor
Note: Binds 1 heme group per subunit.
Pathway
Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 28-32 | substrate | |||
Binding site | 90 | substrate | |||
Binding site | 94 | substrate | |||
Binding site | 217 | Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue | |||
Binding site | 231 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Molecular Function | tryptophan 2,3-dioxygenase activity | |
Biological Process | tryptophan catabolic process to acetyl-CoA | |
Biological Process | tryptophan catabolic process to kynurenine |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTryptophan 2,3-dioxygenase
- EC number
- Short namesTDO
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Novosphingobium
Accessions
- Primary accessionA0A158RZH7
Proteomes
Interaction
Subunit
Homotetramer.
Structure
Sequence
- Sequence statusComplete
- Length259
- Mass (Da)29,364
- Last updated2016-06-08 v1
- ChecksumAE04EE2569719ABB
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CCBH010000139 EMBL· GenBank· DDBJ | CDO35320.1 EMBL· GenBank· DDBJ | Genomic DNA |