A0A158PFT4 · A0A158PFT4_ANGCS

Function

function

Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.

Catalytic activity

  • (2E)-geranial + NADPH + O2 + H+ = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • octan-3-one + NADPH + O2 + H+ = pentyl propanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • octan-3-one + NADPH + O2 + H+ = ethyl hexanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • sulcatone + NADPH + O2 + H+ = 4-methylpent-3-en-1-yl acetate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • NADPH + O2 + H+ = H2O2 + NADP+
    This reaction proceeds in the forward direction.
    EC:1.6.3.1 (UniProtKB | ENZYME | Rhea)
  • heptan-2-one + NADPH + O2 + H+ = pentyl acetate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • heptan-4-one + NADPH + O2 + H+ = propyl butanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • hexan-3-one + NADPH + O2 + H+ = propyl propanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • hexan-3-one + NADPH + O2 + H+ = ethyl butanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionhypotaurine dehydrogenase activity
Molecular FunctionN,N-dimethylaniline monooxygenase activity
Molecular FunctionNAD(P)H oxidase H2O2-forming activity
Molecular FunctionNADP binding
Biological Processlipid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Flavin-containing monooxygenase
  • EC number

Gene names

    • ORF names
      ACOC_LOCUS4369

Organism names

  • Taxonomic identifier
  • Strain
    • Costa Rica
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Strongyloidea > Metastrongylidae > Angiostrongylus

Accessions

  • Primary accession
    A0A158PFT4

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane511-529Helical
Transmembrane536-557Helical

Keywords

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the FMO family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    567
  • Mass (Da)
    65,200
  • Last updated
    2016-06-08 v1
  • Checksum
    0461F292E36B143B
MRVCVVGAAASGLPSIKACLENGIDVICYEKTSDIGGLWNYRPDEKNIGGTVMATTVVNTSKEMMAYSDFPPPEDWPNFMHHSKVNEYLHLYADHYHLKDYIKFNTAVKYITEEKSSFKVQLENGEVEHFDKVILCTGHHAAPYHPQLRDVDKFKGRIMHAHEYRDIKGFEGRNVVLLGIGNSALDIAVDLAKIAKSVTISTRRGTWIFNKVAAGGMPYDTLYMTRYYKWLMDSVPWTIANDFMEHLVQQRMDHELYGLRPNHRFFQQHPTVNDAVANLICSGLITVADDVDTFTADKVIVKNGRSFDCDVFITCTGYVIGFPFLDPKILTIEQNEVSLYKFVFSPNNENLAVIGMIQPIGSILPISEIQARWVAQVFMGKLSLPSKEAMLVDIEMKRKEMKRRYFKSEKHTIQVDYIKYMDEIAMLVGCKPDLWKIFFSDPKFAWRLFMGANAPYVYRLMGPNKWDGAENAIRTIPNRVKRPLKARNCRTRKYKRRGVLDEYFRYMSMKWIAGWSVIIFVTGLSVLCSGTAGMSLLSYCIYTACFFVLFSFMLLWFDMQYNMTTIL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
UYYA01003813
EMBL· GenBank· DDBJ
VDM55954.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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