A0A158PDB2 · A0A158PDB2_ANGCS

Function

function

Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids.

Catalytic activity

  • 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H+
    This reaction proceeds in the forward direction.
    EC:3.1.4.38 (UniProtKB | ENZYME | Rhea)
  • sphing-4-enine-phosphocholine + H2O = sphing-4-enine + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • glycero-2-phosphocholine + H2O = phosphocholine + glycerol + H+
    This reaction proceeds in the forward direction.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

GO annotations

AspectTerm
Cellular Componentmembrane
Biological Processlipid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    glycerophosphocholine cholinephosphodiesterase
  • EC number
  • Alternative names
    • Choline-specific glycerophosphodiester phosphodiesterase
    • Ectonucleotide pyrophosphatase/phosphodiesterase family member 6

Gene names

    • ORF names
      ACOC_LOCUS490

Organism names

  • Taxonomic identifier
  • Strain
    • Costa Rica
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Strongyloidea > Metastrongylidae > Angiostrongylus

Accessions

  • Primary accession
    A0A158PDB2

Proteomes

Subcellular Location

Cell membrane
; Lipid-anchor, GPI-anchor

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-16
ChainPRO_504066956417-466glycerophosphocholine cholinephosphodiesterase

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias352-366Polar residues
Region352-375Disordered

Sequence similarities

Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    466
  • Mass (Da)
    53,145
  • Last updated
    2016-06-08 v1
  • Checksum
    0ED348CEA8AF7BB3
MLTILCLIILFGKSVPKDPIGQNVIVLLIDGYGASLLNESKPETKIGMQHLISHGVQAEYLRSAFPTQSWPNWLSLATGLYTENHGMTADYMWDKETKFSFERGKGVNDSEDIWWDGLPAPLWYTAGKSGVDVHCYWFAHCHRAHYDMVVKVPPKRWTDLNLPEQTDRISQAFPEIVNRIIKYQAYKQQMFLMRYAGVDNALRQFGAHSDEANQAIANIDQYIHELQQKLEEHDLFTSTNLLVLSDHGLAQIEEEEQFYLEECLSDYSKVVKVVNIHSMLMVFTEPQDEGHVHFELRVCDQWAPMGDYEDTDALLVKAYKLSEVPERLHWADSRFMSGVILLTKPGTSIITRELPSVPSPSDHSREARQASGWDPDAPQMRGIFMARGPAFKVDEKTGPIEIVDVYQTLLNILAVEPSHSHNGTWSNVEGMLASGWEERPNSDNFGYAPRICTVFPLMIIPFMLFY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias352-366Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
UYYA01000048
EMBL· GenBank· DDBJ
VDM52075.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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