A0A157ZLT8 · A0A157ZLT8_9BURK
- ProteinPyruvate dehydrogenase E1 component
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids901 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
Catalytic activity
- N6-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + pyruvate + H+ = N6-[(R)-S8-acetyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 242 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 272 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 274 | Mg2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | metal ion binding | |
Molecular Function | pyruvate dehydrogenase (acetyl-transferring) activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePyruvate dehydrogenase E1 component
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Caballeronia
Accessions
- Primary accessionA0A157ZLT8
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-15 | Polar residues | |||
Region | 1-23 | Disordered | |||
Domain | 116-312 | Transketolase N-terminal | |||
Domain | 500-711 | Pyruvate dehydrogenase E1 component middle | |||
Domain | 729-858 | Transketolase-like C-terminal | |||
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length901
- Mass (Da)99,832
- Last updated2016-06-08 v1
- Checksum7B82E04EB97B77A0
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-15 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FCOJ02000004 EMBL· GenBank· DDBJ | SAK46492.1 EMBL· GenBank· DDBJ | Genomic DNA |