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A0A155E069 · A0A155E069_9ENTR

Function

function

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

Catalytic activity

  • Hydrolysis of Ala-|-Gly bond in repressor LexA.
    EC:3.4.21.88 (UniProtKB | ENZYME | Rhea)

Features

Showing features for dna binding, site, active site.

120220406080100120140160180200
Type
IDPosition(s)Description
DNA binding28-48H-T-H motif
Site84-85Cleavage; by autolysis
Active site119For autocatalytic cleavage activity
Active site156For autocatalytic cleavage activity

GO annotations

AspectTerm
Molecular FunctionDNA binding
Molecular Functionserine-type endopeptidase activity
Biological ProcessDNA repair
Biological ProcessDNA replication
Biological Processnegative regulation of DNA-templated transcription
Biological Processproteolysis
Biological ProcessSOS response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    LexA repressor
  • EC number

Gene names

    • Name
      lexA_1
    • Synonyms
      lexA
    • ORF names
      ABF77_01505
      , AYL25_19915
      , B9059_013470
      , HNS33_18410
      , J0A64_20435
      , OIPHN260_02850
      , SAMEA2273443_03281

Organism names

  • Taxonomic identifier
  • Strains
    • GN02692
    • E2161
    • e2161
    • PDA134
    • CRK0054
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Enterobacter > Enterobacter cloacae complex

Accessions

  • Primary accession
    A0A155E069
  • Secondary accessions
    • A0A167QLW0
    • V3DRW6

Proteomes

PTM/Processing

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-65LexA repressor DNA-binding
Domain77-193Peptidase S24/S26A/S26B/S26C

Sequence similarities

Belongs to the peptidase S24 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    202
  • Mass (Da)
    22,204
  • Last updated
    2016-06-08 v1
  • MD5 Checksum
    4FBF219C0DE68E191F1189C0CDA4ABFD
MKALTTRQQEVFDLIRDHIGQTGMPPTRAEIAQRLGFRSPNAAEEHLKALARKGVIEIVSGASRGIRLLVEEETGIPLIGRVAAGEPLLAQQHIEGHYQVDPGMFKPSADFLLRVSGMSMKDIGILDGDLLAVHKTQDVRNGQVVVARIDDEVTVKRLKKQGNTVQLLPENSEFTPIVVDLREQSFSIEGLAVGVIRNGEWL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP023447
EMBL· GenBank· DDBJ
BCL40783.1
EMBL· GenBank· DDBJ
Genomic DNA
LEDI01000003
EMBL· GenBank· DDBJ
KLQ07535.1
EMBL· GenBank· DDBJ
Genomic DNA
JABJWE010000013
EMBL· GenBank· DDBJ
MBA2154824.1
EMBL· GenBank· DDBJ
Genomic DNA
JAFKCP010000017
EMBL· GenBank· DDBJ
MBU3768963.1
EMBL· GenBank· DDBJ
Genomic DNA
LSQV01000005
EMBL· GenBank· DDBJ
OBS90948.1
EMBL· GenBank· DDBJ
Genomic DNA
NEYZ02000055
EMBL· GenBank· DDBJ
RNT40289.1
EMBL· GenBank· DDBJ
Genomic DNA
FKDK01000014
EMBL· GenBank· DDBJ
SAA91306.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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