A0A155E069 · A0A155E069_9ENTR
- ProteinLexA repressor
- GenelexA_1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids202 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
Catalytic activity
Features
Showing features for dna binding, site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
DNA binding | 28-48 | H-T-H motif | |||
Site | 84-85 | Cleavage; by autolysis | |||
Active site | 119 | For autocatalytic cleavage activity | |||
Active site | 156 | For autocatalytic cleavage activity | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | DNA binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | DNA repair | |
Biological Process | DNA replication | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | proteolysis | |
Biological Process | SOS response |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLexA repressor
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Enterobacter > Enterobacter cloacae complex
Accessions
- Primary accessionA0A155E069
- Secondary accessions
Proteomes
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-65 | LexA repressor DNA-binding | |||
Domain | 77-193 | Peptidase S24/S26A/S26B/S26C | |||
Sequence similarities
Belongs to the peptidase S24 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length202
- Mass (Da)22,204
- Last updated2016-06-08 v1
- MD5 Checksum4FBF219C0DE68E191F1189C0CDA4ABFD
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP023447 EMBL· GenBank· DDBJ | BCL40783.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LEDI01000003 EMBL· GenBank· DDBJ | KLQ07535.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JABJWE010000013 EMBL· GenBank· DDBJ | MBA2154824.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAFKCP010000017 EMBL· GenBank· DDBJ | MBU3768963.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LSQV01000005 EMBL· GenBank· DDBJ | OBS90948.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NEYZ02000055 EMBL· GenBank· DDBJ | RNT40289.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FKDK01000014 EMBL· GenBank· DDBJ | SAA91306.1 EMBL· GenBank· DDBJ | Genomic DNA |