A0A154BVI5 · A0A154BVI5_ANASB

Function

function

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site14-16shikimate (UniProtKB | ChEBI)
Binding site61shikimate (UniProtKB | ChEBI)
Active site65Proton acceptor
Binding site77NADP+ (UniProtKB | ChEBI)
Binding site86shikimate (UniProtKB | ChEBI)
Binding site101shikimate (UniProtKB | ChEBI)
Binding site206NADP+ (UniProtKB | ChEBI)
Binding site208shikimate (UniProtKB | ChEBI)
Binding site229NADP+ (UniProtKB | ChEBI)
Binding site236shikimate (UniProtKB | ChEBI)
Binding site278-283ATP (UniProtKB | ChEBI)
Binding site282Mg2+ (UniProtKB | ChEBI)
Binding site300substrate
Binding site324substrate
Binding site346substrate
Binding site382ATP (UniProtKB | ChEBI)
Binding site399substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular FunctionNADP binding
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Molecular Functionshikimate kinase activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processphosphorylation
Biological Processshikimate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Shikimate kinase
  • EC number
  • Short names
    SK
  • Recommended name
    Shikimate dehydrogenase (NADP(+))
  • EC number
  • Short names
    SDH

Gene names

    • Name
      aroE
    • Synonyms
      aroK
    • ORF names
      AXX12_17605

Organism names

  • Taxonomic identifier
  • Strain
    • RU4
  • Taxonomic lineage
    Bacteria > Bacillota > Negativicutes > Selenomonadales > Sporomusaceae > Anaerosporomusa

Accessions

  • Primary accession
    A0A154BVI5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.
Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-88Shikimate dehydrogenase substrate binding N-terminal

Sequence similarities

Belongs to the shikimate dehydrogenase family.
Belongs to the shikimate kinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    433
  • Mass (Da)
    47,969
  • Last updated
    2016-06-08 v1
  • Checksum
    5BBE06EF08CB5F54
MRFYGLLGETLSHSISPEIHGFLFRQLNIEASYSLFPVPPDKLADALYGLILLGSGGVNVTIPYKMKIIPLLDELTDEARALGAVNTVLFRNGRTIGYNTDYAGFGLMLKQHGIEAAGKTAVILGTGGAARTAACWLSDHGAANVKLVSRRPAGAGRFDVLSYNDLTNLTHTDILVNATPVGMYPHIHETPLAKALLTRFGVIIDLIYNPLETRLMREGREQGIYAVNGLTMLAAQAVAAEEIWQGRSIAEELLEPVCEFLSDLPEHTHNLVFIGMPGSGKSTFGRLAADRLGWEFCDTDPYIEQRAGRSISEIFRLEGEEAFRRLETEAIREFSRRRRVVIATGGGAVTRPENMALLEATGRLIYLDRPIEIIATSNLTGRPLLNGDKGKLYSLYEARKPLYERYAHCQVLNKYSLERVLDSIFEDLKRRSN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LSGP01000006
EMBL· GenBank· DDBJ
KYZ77875.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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