A0A154BV73 · A0A154BV73_ANASB

  • Protein
    ATP-dependent helicase/nuclease subunit A
  • Gene
    addA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site22-29ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular ComponentDNA helicase complex
Molecular Function3'-5' DNA helicase activity
Molecular Function3'-5' exonuclease activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functiondouble-stranded DNA binding
Molecular Functionisomerase activity
Biological Processdouble-strand break repair via homologous recombination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent helicase/nuclease subunit A
  • EC number
  • Alternative names
    • ATP-dependent helicase/nuclease AddA
    • DNA 3'-5' helicase AddA

Gene names

    • Name
      addA
    • ORF names
      AXX12_17425

Organism names

  • Taxonomic identifier
  • Strain
    • RU4
  • Taxonomic lineage
    Bacteria > Bacillota > Negativicutes > Selenomonadales > Sporomusaceae > Anaerosporomusa

Accessions

  • Primary accession
    A0A154BV73

Proteomes

Subcellular Location

Interaction

Subunit

Heterodimer of AddA and AddB/RexB.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain1-474UvrD-like helicase ATP-binding
Domain511-817UvrD-like helicase C-terminal
Region531-557Disordered
Compositional bias535-557Polar residues

Sequence similarities

Belongs to the helicase family. AddA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,243
  • Mass (Da)
    138,671
  • Last updated
    2016-06-08 v1
  • Checksum
    F0B4A3C3B5B2C499
MGWSSEQIQAIETRGCNLLVAAAAGSGKTSVLVERIIHQITMPGPQGEEPIDVDRMLVVTFTSAAAAEMRSRIAARIAAMQQQKFSRRLARQAALLNSANISTIHSFCQSVVRKYFYLLDLDPGFRVGAAAEMELLKADVLEQVFADCYEADDPGFSLLIDHYADADGDDTLMQLVLNLYEFSRSHPWPEHWLRQLASRFDLPAETGVDDTPWSNLLRQEILLQLENRAWALDRLIREAEADPDFGAYAETFAADSEIIGELILAARLSWAKLEQAFVGLDFVKLKTVRGGDEDRREYFKSRRDAVKKAVNGIRDSYFARSGADLIVDMRGLTPLVSALAQLVIAFSTAFSQTKRKKSVLDFSDLEHFCLAVLLDESSSPGDPKPSAAALQMRESFAEVLVDEYQDTNGVQETILVLLTRDDPPNRFMVGDVKQSIYRFRLAEPRLFMEKYRSYPSEGIGPCRRIDLAANFRSRALVLHASNFLFGQLMTEAVAELDYGEAERLNPGLDYPPCADSLAGVELHLLERRPQDTEAEQAVVTESESDPAAGQSSHDGSAALDSFSREAAWIASRINQLMQGGHQVYDKETKGYRPLGWRDIVILLRSVQGKAQPMLDLLRAAGIPCYADMDTGYFRETEVGIIVSLLQILDNPRQDIHLAGVLRSPLFHFSGQELALLRVADGGKEHHRDLWDLLLSMAQEETQQPLLKEKTAAFITTIARWRSLARRRSVAELLWLIYEETGFYDYAGGMPGGAFRQANLRALFDRARQYEATNYRGLFRFLRFIEALTARGADLAVARALGENENVVRIMSIHKSKGLEFPVVFVADIGKEINLSDTRELVLCHRDWGIGPYVTLPNQGYRYPTLARWAIAQQLRRETKAEELRILYVALTRARERLILVGSARDLAAKCIAWAESATLGARTLPEAQTAAAKTYLDWIVPALVRHPDGAPLREAAGITDNATPEGLEIDTNSSCWQITLDFTPDTGSDQAEGEQESDLWQQMRQLQPVSVSSDAAEIRRILNWQYPYSAVVGQPAKLTVTEIKRRMAETAAEAKLLYTPTLYSRPRFTGEKKLTGAQLGTVTHLVMQRIQPQLGLTKADIARQVEFMTAAEFLLPEEAAAVDIDAVAAFFTSDLGKRLQQALWVKKELPFSLMLPAERFAPATQGSGDSVFVQGTLDCLFAEADGLVLLDYKTDYTADARQLAERYAVQLSLYAEAVTAIIGQPVKEKFIYSFCRREAVPVE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias535-557Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LSGP01000006
EMBL· GenBank· DDBJ
KYZ77841.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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