A0A154BV73 · A0A154BV73_ANASB
- ProteinATP-dependent helicase/nuclease subunit A
- GeneaddA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1243 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 22-29 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | DNA helicase complex | |
Molecular Function | 3'-5' DNA helicase activity | |
Molecular Function | 3'-5' exonuclease activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | double-stranded DNA binding | |
Molecular Function | isomerase activity | |
Biological Process | double-strand break repair via homologous recombination |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent helicase/nuclease subunit A
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Negativicutes > Selenomonadales > Sporomusaceae > Anaerosporomusa
Accessions
- Primary accessionA0A154BV73
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-474 | UvrD-like helicase ATP-binding | |||
Domain | 511-817 | UvrD-like helicase C-terminal | |||
Region | 531-557 | Disordered | |||
Compositional bias | 535-557 | Polar residues | |||
Sequence similarities
Belongs to the helicase family. AddA subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,243
- Mass (Da)138,671
- Last updated2016-06-08 v1
- ChecksumF0B4A3C3B5B2C499
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 535-557 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LSGP01000006 EMBL· GenBank· DDBJ | KYZ77841.1 EMBL· GenBank· DDBJ | Genomic DNA |