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A0A151BTD4 · A0A151BTD4_9MICO

  • Protein
    4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
  • Gene
    ispG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site282[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site285[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site317[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site324[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Function4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity (ferredoxin)
Molecular Function4-hydroxy-3-methylbut-2-enyl-diphosphate synthase activity (flavodoxin)
Molecular Functioniron ion binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
Biological Processterpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
  • EC number
  • Alternative names
    • 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase

Gene names

    • Name
      ispG
    • ORF names
      AZH51_12515

Organism names

  • Taxonomic identifier
  • Strain
    • NY16-3462-2
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Dermacoccaceae > Branchiibius

Accessions

  • Primary accession
    A0A151BTD4

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the IspG family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    384
  • Mass (Da)
    40,831
  • Last updated
    2016-06-08 v1
  • MD5 Checksum
    00C79B279B4A99D656EA7A71B3FE477E
MSVSLGMPSVKEAPQLIAPRRKSRKIRVGKVEVGGDAPVSVQSMTTTPTTDINATLQQIAELTAAGCDIVRVACPSQDDADALPMIARKSQIPVIADIHFQPKYVFAAIDAGCAGVRVNPGNIRKFDDQVKEIARAAKDAGVSIRIGVNAGSLDKRLLEKYGKPTAEALVESAVWEASLFEEHDFHDFKISVKHNDPVVMVRAYEQLAQRGDWPLHLGVTEAGPAFQGTIKSAVAFGALLSRGIGDTIRVSLSAPPVEEIKVGNQILQSLNLKPRKLEIVSCPSCGRAQVDVYTLAEQVTKGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGEVIKTVPESQIVETLIEEAMRIAEGMEPVEGSAPAVTIS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LVCF01000043
EMBL· GenBank· DDBJ
KYH43175.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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