A0A150IHU7 · A0A150IHU7_9EURY
- Protein3-isopropylmalate dehydratase large subunit
- GeneleuC_2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids418 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Catalytic activity
- (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway
Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3-isopropylmalate dehydratase activity | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | isomerase activity | |
Molecular Function | metal ion binding | |
Biological Process | L-leucine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-isopropylmalate dehydratase large subunit
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Candidatus Methanofastidiosia > Candidatus Methanofastidiosales > Candidatus Methanofastidiosaceae > Candidatus Methanofastidiosum
Accessions
- Primary accessionA0A150IHU7
- Secondary accessions
Proteomes
Interaction
Subunit
Heterodimer of LeuC and LeuD.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 19-284 | Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha | ||||
Sequence: EAGQIVEANVDYVMVNDVTGLPAFEQFEKLPKGTMPLKEKIVLIPDHYVPNKDVASAEQAKRMREFAKKYEIKNYFEVGRGGVCHQLMIEKGFVAPGRLIVGADSHTCSYGALGAFSTGIGSTEAAAVMAIGKLWLKVPDSIKITVNGKLDNYVYGKDIILHVIGDIGVEGALYKAMEYYGNTIENLSLSDRISISNMAIEAGGKAGIIPPDDKVFEYLQERIKGNYNPVYSDKDAYYIEDLKYDAADIPPTVSKPFLPSNTAPAS | ||||||
Domain | 286-409 | Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha | ||||
Sequence: VDVKIDQAYLGSCTNGRIEDLRIAAEILKGRKINPEVRMLVVPASKEVFNQALKEGLIDIFEKADCFVCGPTCGACLGGYMGILADGEKCVATTNRNFIGRMGHKNSEVYLANPAVVAASALEG |
Sequence similarities
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length418
- Mass (Da)45,277
- Last updated2016-06-08 v1
- ChecksumD63CFB46BD77D31A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LNGE01000054 EMBL· GenBank· DDBJ | KYC44583.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LNGF01000006 EMBL· GenBank· DDBJ | KYC48391.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LNJC01000053 EMBL· GenBank· DDBJ | KYC48991.1 EMBL· GenBank· DDBJ | Genomic DNA |