A0A147BGY7 · A0A147BGY7_IXORI

Function

function

Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta24-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Function7-dehydrocholesterol reductase activity
Biological Processbrassinosteroid biosynthetic process
Biological Processcholesterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    7-dehydrocholesterol reductase
  • EC number
  • Alternative names
    • Sterol Delta(7)-reductase

Organism names

  • Taxonomic identifier
  • Strain
    • Siblings of single egg batch collected in Ceske Budejovice
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Parasitiformes > Ixodida > Ixodoidea > Ixodidae > Ixodinae > Ixodes

Accessions

  • Primary accession
    A0A147BGY7

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane307-333Helical
Transmembrane353-377Helical
Transmembrane398-419Helical
Transmembrane425-448Helical
Transmembrane516-537Helical
Transmembrane552-573Helical
Transmembrane585-604Helical
Transmembrane670-688Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-17Basic and acidic residues
Region1-240Disordered
Compositional bias18-66Polar residues
Compositional bias99-113Basic residues
Compositional bias125-140Polar residues

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    718
  • Mass (Da)
    78,374
  • Last updated
    2016-06-08 v1
  • Checksum
    417E462D6A2731F4
ESTADMAPDKKTKTQPSEGRPTTRSNSGSRLASAAARDKSSSPSRGRSPKPSSPGKRQASRSRSRSQGRVGRPKSPGKVGRPKGSGKSPPGRPGRKPSPAKKSPGRKPSPVKKSPARKPPSKSPARSNARASSSDRSPVKSAAPKSPGRKSPARVPAKRADTPRAQSKSPSRPSMAGGRRSVSPAAKEQETNRKGAATPPRLPVGTPGQTVTPRSPLRRRSVPTPWSGAERPDSKGNSVLVEPRVQADKSQVLYTPDRGRGTLRTSARIATMQVTGADDRPDSAVSKKLPEKGKSEKRFAVWESLKAFGWGPTLASLCWLLLLPVLALAVQLLSGSWTLLQPPLVPKSLAAYLRWQLFAGYAGFLLAQALLQALPVGRTVYGFPSKVFKHHVAYKYRLNGWVNLLATAAAFGCLVYYGFPVSAVQLYSLQLLVAVLLTATVLSVLLYIKGRFASRNHRFPGGNTGNVLNDFVVGRELSPRIGEVYDLSALCFRCGLLSWAVLLGCMAWQEFAANKCLGYGFATSAACQLVYICMAFYDEEYYLASVFVTEDALGYVSLVANLALLPLLSSLPARYLHEWRPTMPLYCLASVGAIFLLGLALLHLSHKRKYSFRRNWPDPSSRGQGLDYLLDKSGNRLLVSGLWGLVRHPNYLGDFLCTLAFALPCGFQHALPYTAVLLQALFLVVRVFEVEGKCRQRYGDLWLRYTQRVKYRLLPYVF

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias1-17Basic and acidic residues
Compositional bias18-66Polar residues
Compositional bias99-113Basic residues
Compositional bias125-140Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GEGO01005829
EMBL· GenBank· DDBJ
JAR89575.1
EMBL· GenBank· DDBJ
Transcribed RNA

Similar Proteins

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